Duloxetine
Treatment for Peripheral Neuropathy
Typical Dosage: 30-60 mg daily
Effectiveness
80%
Safety Score
60%
Clinical Trials
43
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
30-60 mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$250
Monitoring:$250
Side Effect Mgmt:$100
Total Annual:$600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,090.91
Cost per Remission
$5,000
Active Clinical Trials
4 active trials recruiting for Duloxetine in Peripheral Neuropathy
Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy
NCT05840562RECRUITINGPHASE3
274 participants
INTERVENTIONAL
Angers, France +10 more
Started: Oct 20, 2023
Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy
NCT05786599RECRUITINGPHASE2, PHASE3
50 participants
INTERVENTIONAL
Nanaimo, Canada +3 more
Started: Mar 21, 2025
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
NCT06614322NOT YET RECRUITINGPHASE2
190 participants
INTERVENTIONAL
Boston, United States +6 more
Started: Jan 1, 2026
Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients with Taxanes-induced Painful Peripheral Neuropathy
NCT04970121RECRUITINGPHASE2
100 participants
INTERVENTIONAL
Bengbu, China
Started: Aug 21, 2021
Completed Clinical Trials
11 completed trials for Duloxetine in Peripheral Neuropathy
A Long-term Study for the Treatment of Painful Diabetic Neuropathy
NCT00641719COMPLETEDPHASE3
258 participants
INTERVENTIONAL
Aichi, Japan +24 more
Started: Mar 1, 2008
A Study for the Treatment of Diabetic Peripheral Neuropathic Pain
NCT00552175COMPLETEDPHASE3
339 participants
INTERVENTIONAL
Aichi, Japan +24 more
Started: Nov 1, 2007
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
NCT00370656COMPLETEDPHASE2, PHASE3
90 participants
INTERVENTIONAL
Bournemouth, United Kingdom +2 more
Started: Feb 1, 2007
Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
NCT00322621COMPLETEDPHASE4
216 participants
INTERVENTIONAL
Fortaleza, Brazil +18 more
Started: Apr 1, 2006
Duloxetine Versus Placebo in the Treatment of Patients With Diabetic Peripheral Neuropathic Pain in China
NCT00408993COMPLETEDPHASE3
215 participants
INTERVENTIONAL
Beijing, China +6 more
Started: Dec 1, 2006
Safety and Efficacy Study of ADL5859 in Participants With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
NCT00603265COMPLETEDPHASE2
226 participants
INTERVENTIONAL
Riverside, United States +26 more
Started: Nov 1, 2007
A Study in Participants With Diabetic Peripheral Neuropathic Pain in China
NCT01179672COMPLETEDPHASE3
405 participants
INTERVENTIONAL
Beijing, China +14 more
Started: Apr 1, 2011
Botulinum Toxin Type A in Diabetic Peripheral Neuropathy
NCT05296759COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Alexandria, Egypt
Started: Feb 1, 2021
Lidocaine Versus Duloxetine for the Prevention of Taxane-Induced Peripheral Neuropathy In Breast Cancer Patients
NCT04732455COMPLETEDNA
60 participants
INTERVENTIONAL
Alexandria, Egypt
Started: Jan 15, 2021
Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain
NCT00266643COMPLETEDPHASE4
205 participants
INTERVENTIONAL
Phoenix, United States +19 more
Started: Dec 1, 2005
An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain
NCT00385671COMPLETEDPHASE4
407 participants
INTERVENTIONAL
Torrance, United States +8 more
Started: Sep 1, 2006
Showing 20 of 43 total trials