DFDA

Azithromycin

Treatment for Pertussis

Typical Dosage: Infants <6 months: 10 mg/kg/day; Older: 500 mg Day 1, then 250 mg daily

Effectiveness
88%
Safety Score
70%
Clinical Trials
4
Participants
15K

Comparative Safety Scale(Higher is safer)

Cyanide☠ī¸
Meth💀
CigarettesđŸšŦ
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AlcoholđŸē
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Infants <6 months: 10 mg/kg/day; Older: 500 mg Day 1, then 250 mg daily
Time to Effect
1-2 days (bacterial eradication)
Treatment Duration
5 days
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$600
Side Effect Mgmt:$5
Total Annual:$625
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$31.25
Cost per Remission
$33.33
Prescription Access Economics
Annual Societal Loss per Patient
$-2,795
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$30/year
Travel + wait time
Insurance Admin Cost
$15/year
Prior auth, claims
Rx Price
$20/year
Potential OTC Price
$10/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Azithromycin Outcomes

for Pertussis

Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+80%
Remission Rate
+75%
Common Side Effects
Diarrhea
+8%
Nausea
+6%
Abdominal pain
+4%
QT prolongation
+0.1%

Sources:

researchgate.net
bmj.com
mdedge.com

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
3 completed trials for Azithromycin in Pertussis

Pertussis Challenge Study in Adults Vaccinated With BPZE1

NCT05461131COMPLETEDPHASE2
View Study
53 participants
INTERVENTIONAL
Oxford, United Kingdom +1 more
Started: Jun 20, 2022

Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure

NCT00469274COMPLETEDNA
View Study
1.1K participants
INTERVENTIONAL
Nashville, United States
Started: May 1, 2007

Periscope Phase C Bordetella Pertussis Human Challenge Study With Delayed Antibiotic Therapy for 6 Weeks

NCT05847322COMPLETEDNA
View Study
19 participants
INTERVENTIONAL
Southampton, United Kingdom
Started: Dec 6, 2022