Erythromycin
Treatment for Pertussis
Typical Dosage: 40-50 mg/kg/day in 4 divided doses
Effectiveness
75%
Safety Score
65%
Clinical Trials
4
Participants
12K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
40-50 mg/kg/day in 4 divided doses
Time to Effect
1-2 days (bacterial eradication)
Treatment Duration
14 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$600
Side Effect Mgmt:$15
Total Annual:$630
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$50
Cost per Remission
$50
Erythromycin Outcomes
for Pertussis
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+60%
Common Side Effects
Diarrhea
+25%
Nausea
+18%
Abdominal pain
+12%
QT prolongation
+0.1%
Sources:
Active Clinical Trials
1 active trial recruiting for Erythromycin in Pertussis
Periscope Phase C Bordetella Pertussis Human Challenge Study With Delayed Antibiotic Therapy for 6 Weeks
NCT05847322RECRUITINGNA
72 participants
INTERVENTIONAL
Southampton, United Kingdom
Started: Dec 6, 2022
Completed Clinical Trials
1 completed trial for Erythromycin in Pertussis
Pertussis Challenge Study in Adults Vaccinated With BPZE1
NCT05461131COMPLETEDPHASE2
53 participants
INTERVENTIONAL
Oxford, United Kingdom +1 more
Started: Jun 20, 2022