DFDA

Trimethoprim-sulfamethoxazole

Treatment for Pertussis

Typical Dosage: Infants >2 months: 8 mg TMP/40 mg SMX/kg/day; Adults/Children: 160 mg TMP/800 mg SMX twice daily

Effectiveness
80%
Safety Score
68%
Clinical Trials
1
Participants
4K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
Infants >2 months: 8 mg TMP/40 mg SMX/kg/day; Adults/Children: 160 mg TMP/800 mg SMX twice daily
Time to Effect
1-2 days (bacterial eradication)
Treatment Duration
14 days
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
12(Treat 12 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$25
Monitoring:$600
Side Effect Mgmt:$10
Total Annual:$635
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
QALYs Gained
0.06
Outcome-Based Costs
Cost per Responder
$58.33
Cost per Remission
$53.85
Prescription Access Economics
Annual Societal Loss per Patient
$-2,792
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$30/year
Travel + wait time
Insurance Admin Cost
$15/year
Prior auth, claims
Rx Price
$25/year
Potential OTC Price
$12/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATE
Missed Diagnosis Risk
LOW
Trimethoprim-sulfamethoxazole Outcomes

for Pertussis

Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+60%
Remission Rate
+65%
Common Side Effects
Nausea
+8%
Diarrhea
+7%
Rash
+2%
Photosensitivity
+4%

Sources:

nih.gov
elsevierpure.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Trimethoprim-sulfamethoxazole in Pertussis

Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure

NCT00469274COMPLETEDNA
View Study
1.1K participants
INTERVENTIONAL
Nashville, United States
Started: May 1, 2007