Clomiphene Citrate (for Ovulation Induction)
Treatment for Polycystic Ovary Syndrome
Typical Dosage: 50-150mg daily for 5 days per cycle
Effectiveness
65%
Safety Score
60%
Clinical Trials
45
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
50-150mg daily for 5 days per cycle
Time to Effect
1-2 menstrual cycles
Treatment Duration
3-6 cycles
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$750
Side Effect Mgmt:$50
Total Annual:$900
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.65
Outcome-Based Costs
Cost per Responder
$1,500
Clomiphene Citrate (for Ovulation Induction) Outcomes
for Polycystic Ovary Syndrome
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+60%
Common Side Effects
Hot flashes
+30%
Ovarian enlargement
+8%
Multiple gestation
+8%
Visual disturbances
+2%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
13 completed trials for Clomiphene Citrate (for Ovulation Induction) in Polycystic Ovary Syndrome
Letrozole Versus Clomifene Citrate for Ovulation Induction
NCT00478504COMPLETEDPHASE4
159 participants
INTERVENTIONAL
Derby, United Kingdom
Started: May 1, 2007
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome
NCT05702957COMPLETEDPHASE2, PHASE3
220 participants
INTERVENTIONAL
Lahore, Pakistan
Started: Sep 1, 2016
Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome
NCT01910766COMPLETEDNA
110 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Jan 1, 2010
Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS
NCT02352597COMPLETEDPHASE4
150 participants
INTERVENTIONAL
Started: Jan 1, 2013
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
NCT06813118COMPLETEDPHASE1
42 participants
INTERVENTIONAL
Rawalpindi, Pakistan
Started: Jun 7, 2024
L-Carnitine and Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome
NCT03476356COMPLETEDNA
106 participants
INTERVENTIONAL
Cairo, Egypt
Started: Nov 1, 2017
Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOS
NCT02436226COMPLETEDPHASE4
300 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Mar 1, 2016
Comparison of Clomiphene Alone Versus Clomiphene Plus Sildenafil for Ovulation in Women With Polycystic Ovary Syndrome
NCT07769476COMPLETEDPHASE4
98 participants
INTERVENTIONAL
Multan, Pakistan
Started: Jul 1, 2025
Clomiphene Citrate Alone Versus Clomiphene Plus Metformin as First Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome
NCT07872501COMPLETEDNA
218 participants
INTERVENTIONAL
Faisalābad, Pakistan
Started: Jan 1, 2025
Clomiphene Stair-Step Protocol for Ovulation Induction in Women With Polycystic Ovarian Syndrome
NCT01953796COMPLETEDNA
140 participants
INTERVENTIONAL
Najaf, Iraq
Started: May 1, 2010
Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS
NCT01909141COMPLETEDEARLY_PHASE1
100 participants
INTERVENTIONAL
Cairo, Egypt
Started: Aug 1, 2013
Adding L-Carnitine to Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome
NCT03630341COMPLETEDPHASE4
150 participants
INTERVENTIONAL
Started: Feb 1, 2016
Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs
NCT02479256COMPLETEDPHASE4
600 participants
INTERVENTIONAL
Cairo, Egypt
Started: Jun 1, 2015
Showing 20 of 48 total trials