Letrozole (for Ovulation Induction)
Treatment for Polycystic Ovary Syndrome
Typical Dosage: 2.5-7.5mg daily for 5 days per cycle
Effectiveness
70%
Safety Score
60%
Clinical Trials
28
Participants
12K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
2.5-7.5mg daily for 5 days per cycle
Time to Effect
1-2 menstrual cycles
Treatment Duration
3-6 cycles
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$750
Side Effect Mgmt:$50
Total Annual:$1,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$1,428
Comparison vs Clomiphene Citrate
Cost Difference
$0/year
Same cost
QALY Difference
+0.15 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Letrozole (for Ovulation Induction) Outcomes
for Polycystic Ovary Syndrome
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Common Side Effects
Hot flashes
+25%
Headache
+15%
Fatigue
+10%
Dizziness
+7%
Multiple gestation
+5%
Sources:
Active Clinical Trials
6 active trials recruiting for Letrozole (for Ovulation Induction) in Polycystic Ovary Syndrome
Combination Letrozole and Clomiphene Citrate Versus Letrozole Alone
NCT06507332RECRUITINGNA
64 participants
INTERVENTIONAL
Cairo, Egypt
Started: Mar 1, 2024
Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients
NCT06405243NOT YET RECRUITINGPHASE3
100 participants
INTERVENTIONAL
Banī Suwayf, Egypt +1 more
Started: Jun 30, 2024
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
NCT07159880RECRUITINGNA
20 participants
INTERVENTIONAL
São Paulo, Brazil
Started: Sep 1, 2025
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
NCT06813118RECRUITINGPHASE1
42 participants
INTERVENTIONAL
Rawalpindi, Pakistan
Started: Jun 7, 2024
Laboratory and Ultrasound Findings and Response to Letrozole in PCOS Patients
NCT06861803NOT YET RECRUITING
138 participants
OBSERVATIONAL
Cairo, Egypt
Started: Apr 1, 2025
Comparative Study Between HOMA1-IR and HOMA2-IR in Prediction of Ovulation Outcome in Women With PCOS
NCT06793904RECRUITINGNA
122 participants
INTERVENTIONAL
Cairo, Egypt
Started: Feb 1, 2025
Completed Clinical Trials
13 completed trials for Letrozole (for Ovulation Induction) in Polycystic Ovary Syndrome
Letrozole and Cabergoline Versus Letrozole Alone in Ovulation Induction
NCT07168837COMPLETEDNA
100 participants
INTERVENTIONAL
Asyut, Egypt
Started: Jan 10, 2023
Letrozole Dose Increments in PCOS Patients Resistant to Letrozole
NCT06403488COMPLETEDPHASE3
102 participants
INTERVENTIONAL
Banī Suwayf, Egypt +1 more
Started: Oct 1, 2023
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
NCT01577017COMPLETEDPHASE3
150 participants
INTERVENTIONAL
Started: May 1, 2008
Letrozole Step up Protocol for Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome
NCT07143682COMPLETEDPHASE3
70 participants
INTERVENTIONAL
Dhaka, Bangladesh
Started: Jan 8, 2023
Letrozole Alone Protocol Versus Using Letrozole and HCG Protocol
NCT06367712COMPLETEDPHASE1
132 participants
INTERVENTIONAL
Cairo, Egypt
Started: Nov 10, 2022
Letrozole Versus Clomifene Citrate for Ovulation Induction
NCT00478504COMPLETEDPHASE4
159 participants
INTERVENTIONAL
Derby, United Kingdom
Started: May 1, 2007
Letrozole or Laparoscopic Ovarian Diathermy for Women With CC Resistant Polycystic Ovary Syndrome.
NCT00956267COMPLETEDNA
260 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Aug 1, 2006
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome
NCT05702957COMPLETEDPHASE2, PHASE3
220 participants
INTERVENTIONAL
Lahore, Pakistan
Started: Sep 1, 2016
Ovulation Induction in Clomiphene Citrate Resistant PCO Women
NCT02341703COMPLETEDEARLY_PHASE1
100 participants
INTERVENTIONAL
Cairo, Egypt
Started: Feb 1, 2015
Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole
NCT03440359COMPLETEDPHASE2, PHASE3
52 participants
INTERVENTIONAL
Norfolk, United States
Started: Jul 6, 2012
Letrozole or Combined Metformin Clomiphene Citrate (CC) for Women With CC Resistant Polycystic Ovary Syndrome
NCT00911313COMPLETEDNA
250 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Jun 1, 2006
Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS
NCT01909141COMPLETEDEARLY_PHASE1
100 participants
INTERVENTIONAL
Cairo, Egypt
Started: Aug 1, 2013
Comparison Between Two Ovulation Induction Therapies and LOD on Clinical Outcomes in CC-Resistant PCOS Women
NCT06486870COMPLETEDPHASE3
183 participants
INTERVENTIONAL
Cairo, Egypt
Started: Jan 1, 2020
Showing 20 of 29 total trials