Metformin
Treatment for Polycystic Ovary Syndrome
Typical Dosage: 1500-2000mg daily
Effectiveness
75%
Safety Score
65%
Clinical Trials
200
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
1500-2000mg daily
Time to Effect
3-6 months
Treatment Duration
long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10000(Treat 10000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$275
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$458
Cost per Remission
$2,750
Metformin Outcomes
for Polycystic Ovary Syndrome
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+10%
Common Side Effects
Diarrhea
+25%
Nausea
+20%
Abdominal discomfort
+15%
Vitamin B12 deficiency
+8%
Lactic acidosis
+0.001%
Active Clinical Trials
2 active trials recruiting for Metformin in Polycystic Ovary Syndrome
Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome
NCT06576375RECRUITINGPHASE3
70 participants
INTERVENTIONAL
Giza, Egypt
Started: Sep 2, 2024
Adjuvant Therapy With Letrozole in Induction of Ovulation With Polycystic Ovarian Syndrome
NCT06405178NOT YET RECRUITINGPHASE3
500 participants
INTERVENTIONAL
Banī Suwayf, Egypt
Started: Sep 30, 2024
Completed Clinical Trials
13 completed trials for Metformin in Polycystic Ovary Syndrome
Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET)
NCT02086526COMPLETEDPHASE1
68 participants
INTERVENTIONAL
Rochester, United States
Started: Mar 1, 2014
Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome
NCT01474967COMPLETEDNA
50 participants
INTERVENTIONAL
Bandarabbas, Iran
Started: Feb 1, 2010
Spironolactone Plus Metformin in Polycystic Ovary Syndrome
NCT01526616COMPLETEDNA
56 participants
INTERVENTIONAL
Started: May 1, 2010
Study to Assess the Effect of Metformin Supplementation on IVF Outcome in Patients With Polycystic Ovarian Syndrome.
NCT03086005COMPLETEDPHASE3
24 participants
INTERVENTIONAL
Seoul, South Korea
Started: Oct 12, 2011
Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study
NCT03259919COMPLETEDPHASE2
40 participants
INTERVENTIONAL
Trondheim, Norway
Started: Oct 1, 2000
Metformin Treatment in Adolescent Patients With PCOS: A Long-term, Winning Metabolic Choice.
NCT06015594COMPLETEDNA
168 participants
INTERVENTIONAL
Started: Jan 1, 2015
Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome
NCT00670800COMPLETEDNA
14 participants
INTERVENTIONAL
Ann Arbor, United States
Started: Jan 1, 2008
Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome
NCT02498522COMPLETEDEARLY_PHASE1
166 participants
INTERVENTIONAL
Cairo, Egypt
Started: Aug 1, 2015
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
NCT00795808COMPLETEDPHASE4
171 participants
INTERVENTIONAL
Auckland, New Zealand
Started: Aug 1, 2003
Effects of Combined Metformin and Cabergoline in Comparison With Metformin Only Therapy on Ovarian and Hormonal Activities in Iraqi Patients With PCOS
NCT05981742COMPLETEDPHASE2
75 participants
INTERVENTIONAL
Al Qādisīyah, Iraq
Started: Sep 21, 2022
Trial With Metformin in Women With Polycystic Ovary Syndrome
NCT02280057COMPLETEDPHASE4
56 participants
INTERVENTIONAL
Herning, Denmark
Started: Sep 1, 2001
Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome
NCT00679679COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Córdoba, Argentina
Started: Jan 1, 2003
Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome
NCT03117517COMPLETEDEARLY_PHASE1
106 participants
INTERVENTIONAL
Mardan, Pakistan
Started: Mar 20, 2017
Showing 20 of 203 total trials