DFDA

Combined Oral Contraceptives (Drospirenone/Ethinyl Estradiol)

Treatment for Premenstrual Syndrome

Typical Dosage: One pill daily

Effectiveness
70%
Safety Score
60%
Clinical Trials
8
Participants
8K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
60
DangerousModerateSafe
Treatment Details
Dosage Range
One pill daily
Time to Effect
1-3 cycles
Treatment Duration
Continuous
Evidence Quality
HIGH
Number Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$450
Monitoring:$150
Side Effect Mgmt:$100
Total Annual:$700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$95,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,167
Cost per Remission
$2,333
Comparison vs Placebo
Cost Difference
+$700/year
More expensive
QALY Difference
+0.07 QALYs
Better outcomes
Dominance
No dominance
Combined Oral Contraceptives (Drospirenone/Ethinyl Estradiol) Outcomes

for Premenstrual Syndrome

Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Remission Rate
+30%
Common Side Effects
Nausea
+15%
Breast tenderness
+20%
Headache
+10%
Venous Thromboembolism (rare)
+0.1%

Sources:

nih.gov
cochranelibrary.com
cochrane.org

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
5 completed trials for Combined Oral Contraceptives (Drospirenone/Ethinyl Estradiol) in Premenstrual Syndrome

The Oral Contraceptive Pill for Premenstrual Worsening of Depression

NCT00633360COMPLETEDNA
View Study
32 participants
INTERVENTIONAL
Boston, United States
Started: Feb 1, 2008

Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder

NCT05098574COMPLETEDPHASE2
View Study
17 participants
INTERVENTIONAL
Hamilton, Canada
Started: Feb 3, 2023

Premenstrual Symptoms Treatment Comparing Between Oral Contraceptives Containing Desogestrel and Drospirenone

NCT01482338COMPLETEDPHASE4
View Study
90 participants
INTERVENTIONAL
Bangkok, Thailand
Started: Jun 1, 2011

Comparison Between Oral Contraceptive Pills and Calcium Supplements in Treatment of Premenstrual Syndrome

NCT02089620COMPLETEDPHASE3
View Study
210 participants
INTERVENTIONAL
BanΔ« Suwayf, Egypt
Started: May 1, 2014

Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)

NCT00927095COMPLETEDPHASE4
View Study
67 participants
INTERVENTIONAL
Chapel Hill, United States
Started: Jul 1, 2008