DFDA

Pregabalin

Treatment for Restless Legs Syndrome

Typical Dosage: 150-450 mg daily

Effectiveness
78%
Safety Score
62%
Clinical Trials
7
Participants
4K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
62
DangerousModerateSafe
Treatment Details
Dosage Range
150-450 mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$360
Monitoring:$300
Side Effect Mgmt:$50
Total Annual:$710
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$25,000/QALY
QALYs Gained
0.25
Outcome-Based Costs
Cost per Responder
$979
Cost per Remission
$2,367
Comparison vs Pramipexole
Cost Difference
+$180/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Pregabalin Outcomes

for Restless Legs Syndrome

Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+72%
Remission Rate
+30%
Common Side Effects
Dizziness
+25%
Somnolence
+20%
Weight gain
+7%

Sources:

semanticscholar.org
bvsalud.org
neurology-asia.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Pregabalin in Restless Legs Syndrome

Quality Improvement and Practice Based Research in Neurology Using the EMR

NCT02670161ENROLLING BY INVITATIONPHASE4
View Study
3.3K participants
INTERVENTIONAL
Evanston, United States
Started: May 1, 2016
Completed Clinical Trials
4 completed trials for Pregabalin in Restless Legs Syndrome

Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients

NCT00676403COMPLETEDPHASE2
View Study
137 participants
INTERVENTIONAL
Tuscaloosa, United States +24 more
Started: Apr 1, 2008

RCT for Pregabalin in Restless Legs Syndrome in South Korea

NCT04161027COMPLETEDPHASE3
View Study
116 participants
INTERVENTIONAL
Seoul, South Korea
Started: Feb 24, 2020

Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

NCT00991276COMPLETEDPHASE3
View Study
85 participants
INTERVENTIONAL
Jasper, United States +40 more
Started: Dec 1, 2009

Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients

NCT00806026COMPLETEDPHASE3
View Study
731 participants
INTERVENTIONAL
Birmingham, United States +109 more
Started: Dec 1, 2008