Ropinirole
Treatment for Restless Legs Syndrome
Typical Dosage: 0.25-4 mg daily
Effectiveness
78%
Safety Score
58%
Clinical Trials
25
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
0.25-4 mg daily
Time to Effect
1-3 days
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$180
Monitoring:$300
Side Effect Mgmt:$50
Total Annual:$530
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$10,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$757
Cost per Remission
$2,120
Ropinirole Outcomes
for Restless Legs Syndrome
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+70%
Remission Rate
+25%
Common Side Effects
Nausea
+15%
Somnolence
+15%
Dizziness
+10%
Augmentation (long-term)
+30%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
19 completed trials for Ropinirole in Restless Legs Syndrome
A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome
NCT00363857COMPLETEDPHASE3
360 participants
INTERVENTIONAL
Alabaster, United States +48 more
Started: Aug 1, 2003
REQUIP RLS Post Marketing Surveillance
NCT01327339COMPLETED
755 participants
OBSERVATIONAL
Started: Apr 1, 2006
Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome)
NCT00256854COMPLETEDPHASE3
135 participants
INTERVENTIONAL
Laguna Hills, United States +29 more
Started: Nov 14, 2005
A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS)
NCT00225862COMPLETEDPHASE3
140 participants
INTERVENTIONAL
Alabaster, United States +36 more
Started: Jan 1, 2005
Long-term Study Of Ropinirole In Restless Legs Syndrome
NCT00329602COMPLETEDPHASE4
404 participants
INTERVENTIONAL
Camperdown, Australia +38 more
Started: Mar 1, 2006
Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food
NCT00419692COMPLETEDPHASE1
32 participants
INTERVENTIONAL
Berlin, Germany +1 more
Started: Aug 24, 2006
12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome
NCT00373542COMPLETEDPHASE4
39 participants
INTERVENTIONAL
Jasper, United States +44 more
Started: Oct 1, 2006
Ropinirole Tablets In Young Patients With Restless Legs Syndrome
NCT00140712COMPLETEDPHASE1
9 participants
INTERVENTIONAL
Washington D.C., United States +8 more
Started: Jun 10, 2005
Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome
NCT00355641COMPLETEDPHASE3
450 participants
INTERVENTIONAL
Alabaster, United States +64 more
Started: Oct 1, 2005
Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS)
NCT00367822COMPLETEDPHASE3
300 participants
INTERVENTIONAL
Nuremberg, Germany
Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrome
NCT00530790COMPLETEDPHASE2
35 participants
INTERVENTIONAL
Fukuoka, Japan +10 more
Started: Aug 23, 2007
Ropinirole XR (Extended Release) In Patients With Restless Legs Syndrome
NCT00197080COMPLETEDPHASE3
380 participants
INTERVENTIONAL
Alabaster, United States +69 more
Started: Jun 1, 2005
RLS In Adults: Comparing Immediate Release Formulation With Extended Release Formulation Of Ropinirole
NCT00314860COMPLETEDPHASE3
568 participants
INTERVENTIONAL
Birmingham, United States +90 more
Started: Feb 1, 2006
The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrome
NCT00357097COMPLETEDPHASE3
240 participants
INTERVENTIONAL
Ellwangen, Germany +49 more
Started: Jun 1, 2006
SWITCH:Restless Legs Patients Switched to Ropinirole From Pramipexole
NCT00344994COMPLETEDPHASE4
20 participants
INTERVENTIONAL
Augusta, United States
Started: May 1, 2006
DIalysis Symptom COntrol-Restless Legs Syndrome Trial
NCT03806530COMPLETEDPHASE3
52 participants
INTERVENTIONAL
Halifax, Canada +2 more
Started: May 1, 2019
A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole
NCT00422994COMPLETEDPHASE1
48 participants
INTERVENTIONAL
Minneapolis, United States +1 more
Started: Apr 1, 2006
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome
NCT00051961COMPLETED
90 participants
OBSERVATIONAL
Bethesda, United States
Started: Jan 14, 2003
A Single-Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Under Fed Conditions
NCT00674310COMPLETEDNA
29 participants
INTERVENTIONAL
Started: Feb 1, 2004
Showing 20 of 25 total trials