DFDA

External Beam Radiation Therapy (EBRT)

Treatment for Retinoblastoma

Typical Dosage: 40-45 Gy in 1.8-2.0 Gy fractions

Effectiveness
80%
Safety Score
25%
Clinical Trials
4
Participants
5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
40-45 Gy in 1.8-2.0 Gy fractions
Time to Effect
1-3 months
Treatment Duration
3-6 weeks
Evidence Quality
HIGH
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$30,000
Side Effect Mgmt:$15,000
Total Annual:$45,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
QALYs Gained
12.5
Outcome-Based Costs
Cost per Responder
$56,250
Cost per Remission
$64,286
Comparison vs Systemic Chemotherapy
Cost Difference
+$10,000/year
More expensive
QALY Difference
-3.00 QALYs
Worse outcomes
Dominance
No dominance
External Beam Radiation Therapy (EBRT) Outcomes

for Retinoblastoma

Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+70%
Common Side Effects
Cataract
+80%
Radiation retinopathy/optic neuropathy
+60%
Orbital bone hypoplasia/facial asymmetry
+50%
Dry eye/conjunctivitis
+40%
Secondary malignancies
+10%

Sources:

nih.gov
mdpi.com
medcraveonline.com

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
3 active trials recruiting for External Beam Radiation Therapy (EBRT) in Retinoblastoma

MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH)

NCT03026998ACTIVE NOT RECRUITINGNA
View Study
88 participants
INTERVENTIONAL
Paris, France
Started: Mar 19, 2017

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

NCT01783535ACTIVE NOT RECRUITINGPHASE2
View Study
174 participants
INTERVENTIONAL
Memphis, United States
Started: Jun 19, 2013

Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)

NCT02870907ACTIVE NOT RECRUITINGPHASE2
View Study
195 participants
INTERVENTIONAL
Saint-Denis, France +26 more
Started: Mar 18, 2010
Completed Clinical Trials
1 completed trial for External Beam Radiation Therapy (EBRT) in Retinoblastoma

Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma

NCT00186888COMPLETEDPHASE3
View Study
107 participants
INTERVENTIONAL
Memphis, United States
Started: Apr 7, 2005