DFDA

Warfarin

Treatment for Rheumatic Heart Disease

Typical Dosage: 1-10mg daily (INR adjusted)

Effectiveness
90%
Safety Score
55%
Clinical Trials
2
Participants
75K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
1-10mg daily (INR adjusted)
Time to Effect
3-5 days (to therapeutic INR)
Treatment Duration
lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
40(Treat 40 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
150(Treat 150 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$440
Side Effect Mgmt:$150
Total Annual:$620
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$20,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$705
Warfarin Outcomes

for Rheumatic Heart Disease

Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+88%
Common Side Effects
Minor bleeding (bruising, nosebleeds)
+10%
Major bleeding (GI, intracranial)
+3%

Sources:

dntb.gov.ua
researchgate.net
rhdaction.org

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Warfarin in Rheumatic Heart Disease

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority

NCT02832544COMPLETEDPHASE3
View Study
4.57K participants
INTERVENTIONAL
Gaborone, Botswana +138 more
Started: Aug 22, 2016