Etanercept
Treatment for Rheumatoid Arthritis
Typical Dosage: 50 mg once weekly (subcutaneous)
Effectiveness
82%
Safety Score
42%
Clinical Trials
196
Participants
70K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
42
DangerousModerateSafe
Treatment Details
Dosage Range
50 mg once weekly (subcutaneous)
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
92%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$60,000
Monitoring:$1,500
Side Effect Mgmt:$1,000
Total Annual:$62,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$115,000/QALY
QALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$89,285.71
Cost per Remission
$208,333.33
Comparison vs Methotrexate
Cost Difference
+$60,900/year
More expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
No dominance
Etanercept Outcomes
for Rheumatoid Arthritis
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+70%
Remission Rate
+30%
Common Side Effects
Injection site reactions
+20%
Upper respiratory tract infections
+15%
Headache
+10%
Nausea
+8%
Serious infections (e.g., TB, sepsis)
+3%
Malignancy (rare)
+1%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
14 completed trials for Etanercept in Rheumatoid Arthritis
Study With Etanercept Focusing on Remission and Predictability of Remission in Real Life Clinical Practice
NCT02202837COMPLETED
157 participants
OBSERVATIONAL
Yvoir, Belgium +34 more
Started: Aug 12, 2014
Randomized Double-blind Parallel Trial to Evaluate Equivalence in Efficacy and Safety of HD203 and Enbrel in RA Patients
NCT01270997COMPLETEDPHASE3
294 participants
INTERVENTIONAL
Seoul, South Korea
Started: Dec 1, 2010
Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid Arthritis
NCT00913458COMPLETEDPHASE4
306 participants
INTERVENTIONAL
Lyon, France +58 more
Started: Sep 1, 2009
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis
NCT00361634COMPLETEDPHASE1
14 participants
INTERVENTIONAL
Los Angeles, United States +2 more
Started: Sep 1, 2006
Prospective Evaluation of the Radiographic Efficacy of Enbrel
NCT01623752COMPLETED
1.82K participants
OBSERVATIONAL
Started: Feb 1, 2012
This Study is to Investigate the Effect of Etanercept in Early Versus Delayed Referral for Management of Rheumatoid Arthritis Patients.
NCT04267614COMPLETED
1.23K participants
OBSERVATIONAL
Baghdad, Iraq
Started: Nov 1, 2018
Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)
NCT02115750COMPLETEDPHASE3
647 participants
INTERVENTIONAL
Phoenix, United States +140 more
Started: May 1, 2014
An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid Arthritis
NCT00346294COMPLETEDPHASE4
115 participants
INTERVENTIONAL
Started: Jan 1, 2006
Evaluation of EULAR-RAID Score in Rheumatoid Arthritis Patients
NCT00768053COMPLETEDPHASE4
108 participants
INTERVENTIONAL
Amiens, France +16 more
Started: Oct 1, 2008
Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Rheumatoid Arthritis
NCT00445770COMPLETEDPHASE3
550 participants
INTERVENTIONAL
Nagoya, Japan +40 more
Started: Jul 1, 2006
Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA
NCT00858780COMPLETEDPHASE4
91 participants
INTERVENTIONAL
Glostrup Municipality, Denmark +15 more
Started: Jan 1, 2009
Etanercept SFP in RA Patients
NCT00413452COMPLETEDPHASE3
224 participants
INTERVENTIONAL
Started: Dec 1, 2006
Study Evaluating Enbrel In Adults With Active Rheumatoid Arthritis In Luxemburg
NCT00195338COMPLETED
25 participants
OBSERVATIONAL
Luxembourg, Luxembourg
Started: May 1, 2004
Preference of Rheumatoid Arthritis (RA) Patients of Enbrel® (Etanercept) Auto-Injector Versus Enbrel® Pre-Filled Syringes
NCT00094341COMPLETEDPHASE4
215 participants
INTERVENTIONAL
Started: Oct 1, 2004
Showing 20 of 196 total trials