Metronidazole (topical)
Treatment for Rosacea
Typical Dosage: Apply once or twice daily
Effectiveness
65%
Safety Score
85%
Clinical Trials
9
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
85
DangerousModerateSafe
Treatment Details
Dosage Range
Apply once or twice daily
Time to Effect
3-6 weeks
Treatment Duration
9-12 weeks initial, then as needed or maintenance
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$300
Side Effect Mgmt:$50
Total Annual:$850
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$18,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$1,465
Cost per Remission
$3,400
Prescription Access Economics
Annual Societal Loss per Patient
$700
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$80/year
Prior auth, claims
Rx Price
$500/year
Potential OTC Price
$150/year
Estimated if OTC available
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWMetronidazole (topical) Outcomes
for Rosacea
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+58%
Remission Rate
+25%
Common Side Effects
Dryness/irritation/burning
+10%
Erythema
+2%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
9 completed trials for Metronidazole (topical) in Rosacea
A Therapeutic Equivalence Study of Two Metronidazole 1%Topical Gel Treatments for Patients With Rosacea
NCT01513863COMPLETEDPHASE1
602 participants
INTERVENTIONAL
Phoenix, United States +21 more
Started: Aug 1, 2011
A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea
NCT02393937COMPLETEDPHASE3
963 participants
INTERVENTIONAL
Los Angeles, United States +26 more
Started: Feb 1, 2015
An Evaluation of the Cosmetic Appearance of Metronidazole Gel (MetroGel®) 1%
NCT00668655COMPLETED
30 participants
OBSERVATIONAL
High Point, United States
Started: Feb 1, 2008
Study to Evaluate the Efficacy and Safety of PAC-14028 Cream in Rosacea Patients
NCT02052999COMPLETEDPHASE2
80 participants
INTERVENTIONAL
Seoul, South Korea
Started: Feb 1, 2013
Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea
NCT00855595COMPLETEDPHASE4
207 participants
INTERVENTIONAL
Birmingham, United States +16 more
Started: Feb 1, 2009
Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo
NCT01426269COMPLETEDPHASE4
235 participants
INTERVENTIONAL
Santa Monica, United States +10 more
Started: Sep 1, 2011
Preferences & Treatment Satisfaction Drivers in Rosacea Patients
NCT02602470COMPLETED
206 participants
OBSERVATIONAL
Boston, United States
Started: Jan 8, 2015
Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens
NCT00495313COMPLETEDPHASE4
91 participants
INTERVENTIONAL
Omaha, United States +6 more
Started: Mar 1, 2007
Evaluation of the Efficacy and Tolerance of Two Cosmetic Products in Subjects With Rosacea
NCT06582043COMPLETEDNA
70 participants
INTERVENTIONAL
Ciudad Autónoma de Buenos Aire, Argentina +1 more
Started: May 16, 2024