Oxymetazoline (topical)
Treatment for Rosacea
Typical Dosage: Pea-sized amount once daily
Effectiveness
70%
Safety Score
80%
Clinical Trials
2
Participants
1.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
Pea-sized amount once daily
Time to Effect
Within 1 hour
Treatment Duration
Daily, as needed
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
25(Treat 25 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$3,000
Monitoring:$300
Side Effect Mgmt:$150
Total Annual:$3,450
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$16,929/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$5,948
Comparison vs Topical Brimonidine
Cost Difference
+$200/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$2,350
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$80/year
Prior auth, claims
Rx Price
$3,000/year
Potential OTC Price
$1,000/year
Estimated if OTC available
Risk Assessment
Misuse Risk
MODERATEMissed Diagnosis Risk
LOWOxymetazoline (topical) Outcomes
for Rosacea
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+58%
Common Side Effects
Application site reactions (pain, erythema, pruritus)
+5%
Rebound erythema
+5%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
2 completed trials for Oxymetazoline (topical) in Rosacea
An Evaluation of the Reduction in Erythema in Adult Patients With Moderate to Severe Persistent Facial Erythema Associated With Rosacea
NCT03352323COMPLETEDPHASE3
50 participants
INTERVENTIONAL
College Station, United States
Started: Oct 18, 2017
Pulsed Dye Laser Treatment and Oxymetazoline Hydrochloride (HCL) 1% Cream for Erythematotelangiectatic Rosacea
NCT04153188COMPLETEDPHASE4
34 participants
INTERVENTIONAL
Charlotte, United States +1 more
Started: Jan 15, 2019