Metrifonate
Treatment for Schistosomiasis
Typical Dosage: 7.5-10 mg/kg body weight, three doses at 2-week intervals
Effectiveness
65%
Safety Score
60%
Clinical Trials
50
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
7.5-10 mg/kg body weight, three doses at 2-week intervals
Time to Effect
Rapid for parasite killing, weeks-months for symptom improvement
Treatment Duration
3 doses over 4 weeks
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$40
Side Effect Mgmt:$30
Total Annual:$85
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$800/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$113.33
Cost per Remission
$141.67
Comparison vs Praziquantel
Cost Difference
+$30/year
More expensive
QALY Difference
-0.30 QALYs
Worse outcomes
Dominance
No dominance
Metrifonate Outcomes
for Schistosomiasis
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+75%
Remission Rate
+60%
Common Side Effects
Abdominal pain
+30%
Nausea
+25%
Dizziness
+20%
Fatigue
+18%
Sweating
+7%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov