DFDA

Oral Appliance Therapy (OAT)

Treatment for Sleep Apnea

Typical Dosage: Custom-fitted, adjustable appliance

Effectiveness
75%
Safety Score
85%
Clinical Trials
2
Participants
50K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
85
DangerousModerateSafe
Treatment Details
Dosage Range
Custom-fitted, adjustable appliance
Time to Effect
1-4 weeks
Treatment Duration
Lifetime
Evidence Quality
HIGH
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$750
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$60,000/QALY
QALYs Gained
0.5
Outcome-Based Costs
Cost per Responder
$1,250
Cost per Remission
$1,500
Comparison vs CPAP
Cost Difference
$0/year
Same cost
QALY Difference
-0.25 QALYs
Worse outcomes
Dominance
No dominance
Oral Appliance Therapy (OAT) Outcomes

for Sleep Apnea

Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+50%
Common Side Effects
Jaw discomfort
+40%
Dry mouth/excessive salivation
+25%
Dental/occlusal changes (long-term)
+15%
TMJ pain
+7%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Oral Appliance Therapy (OAT) in Sleep Apnea

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

NCT05988385RECRUITINGNA
View Study
200 participants
INTERVENTIONAL
Tucson, United States +3 more
Started: Apr 22, 2024
Completed Clinical Trials
1 completed trial for Oral Appliance Therapy (OAT) in Sleep Apnea

Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy

NCT03011762COMPLETEDNA
View Study
202 participants
INTERVENTIONAL
Started: Nov 1, 2012