DFDA

Uvulopalatopharyngoplasty (UPPP)

Treatment for Sleep Apnea

Typical Dosage: Surgical procedure

Effectiveness
55%
Safety Score
60%
Clinical Trials
8
Participants
10K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Surgical procedure
Time to Effect
4-6 weeks (post-recovery)
Treatment Duration
One-time procedure
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$100
Side Effect Mgmt:$200
Total Annual:$2,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$120,000/QALY
QALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$5,000
Cost per Remission
$10,000
Comparison vs CPAP
Cost Difference
+$1,700/year
More expensive
QALY Difference
-0.35 QALYs
Worse outcomes
Dominance
No dominance
Uvulopalatopharyngoplasty (UPPP) Outcomes

for Sleep Apnea

Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+50%
Remission Rate
+25%
Common Side Effects
Post-operative pain
+85%
Swallowing difficulties/nasal regurgitation
+20%
Voice change
+10%
Bleeding/infection
+5%

Sources:

nih.gov
researchgate.net
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
2 active trials recruiting for Uvulopalatopharyngoplasty (UPPP) in Sleep Apnea

Developing a Treatment Clustering System for Obstructive Sleep Apnea Using Polysomnographic Physiological Signals

NCT06512779RECRUITINGNA
View Study
150 participants
INTERVENTIONAL
Tainan, Taiwan
Started: Jul 30, 2024

Precision Health and Smart Telerehabilitation in OSA

NCT07254026RECRUITINGNA
View Study
300 participants
INTERVENTIONAL
Tainan, Taiwan
Started: Oct 15, 2025
Completed Clinical Trials
4 completed trials for Uvulopalatopharyngoplasty (UPPP) in Sleep Apnea

Combined RF Surgery of the Tongue Base and Uvulopalatopharyngoplasty (UPPP) for Obstructive Sleep Apnea

NCT01259154COMPLETED
View Study
OBSERVATIONAL
Prague, Czechia

Study of Effects of Sutures on Results of Palate Surgery for Obstructive Sleep Apnea

NCT00205543COMPLETEDNA
View Study
16 participants
INTERVENTIONAL
Richmond, United States
Started: Jul 1, 2004

Measuring Effectiveness in Sleep Apnea Surgery

NCT00518128COMPLETEDNA
View Study
60 participants
INTERVENTIONAL
San Francisco, United States
Started: Jul 1, 2007

Treatment of Obstructive Sleep Apnea (OSA) With the da Vinci® SP™ Surgical System

NCT04795817COMPLETED
View Study
25 participants
OBSERVATIONAL
Seoul, South Korea
Started: Jan 27, 2021