Uvulopalatopharyngoplasty (UPPP)
Treatment for Sleep Apnea
Typical Dosage: Surgical procedure
Effectiveness
55%
Safety Score
60%
Clinical Trials
8
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Surgical procedure
Time to Effect
4-6 weeks (post-recovery)
Treatment Duration
One-time procedure
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$100
Side Effect Mgmt:$200
Total Annual:$2,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$120,000/QALY
QALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$5,000
Cost per Remission
$10,000
Comparison vs CPAP
Cost Difference
+$1,700/year
More expensive
QALY Difference
-0.35 QALYs
Worse outcomes
Dominance
No dominance
Uvulopalatopharyngoplasty (UPPP) Outcomes
for Sleep Apnea
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+50%
Remission Rate
+25%
Common Side Effects
Post-operative pain
+85%
Swallowing difficulties/nasal regurgitation
+20%
Voice change
+10%
Bleeding/infection
+5%
Sources:
Active Clinical Trials
2 active trials recruiting for Uvulopalatopharyngoplasty (UPPP) in Sleep Apnea
Effects of Surgery on Oral Frailty and Dysphagia in Patients With Obstructive Sleep Apnea
NCT07880067RECRUITING
450 participants
OBSERVATIONAL
Kaohsiung City, Taiwan
Started: Jun 12, 2026
Precision Health and Smart Telerehabilitation in OSA
NCT07254026RECRUITINGNA
300 participants
INTERVENTIONAL
Tainan, Taiwan
Started: Oct 15, 2025
Completed Clinical Trials
4 completed trials for Uvulopalatopharyngoplasty (UPPP) in Sleep Apnea
Combined RF Surgery of the Tongue Base and Uvulopalatopharyngoplasty (UPPP) for Obstructive Sleep Apnea
NCT01259154COMPLETED
OBSERVATIONAL
Prague, Czechia
Study of Effects of Sutures on Results of Palate Surgery for Obstructive Sleep Apnea
NCT00205543COMPLETEDNA
16 participants
INTERVENTIONAL
Richmond, United States
Started: Jul 1, 2004
Measuring Effectiveness in Sleep Apnea Surgery
NCT00518128COMPLETEDNA
60 participants
INTERVENTIONAL
San Francisco, United States
Started: Jul 1, 2007
Treatment of Obstructive Sleep Apnea (OSA) With the da Vinci® SP™ Surgical System
NCT04795817COMPLETED
25 participants
OBSERVATIONAL
Seoul, South Korea
Started: Jan 27, 2021