Surgical Clipping
Treatment for Subarachnoid Hemorrhage
Typical Dosage: N/A (procedure)
Effectiveness
88%
Safety Score
45%
Clinical Trials
19
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
N/A (procedure)
Time to Effect
Immediate
Treatment Duration
One-time procedure
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$3,000
Side Effect Mgmt:$2,000
Total Annual:$5,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.7
Comparison vs Endovascular Coiling
Cost Difference
+$20,000/year
More expensive
QALY Difference
-0.10 QALYs
Worse outcomes
Dominance
No dominance
Surgical Clipping Outcomes
for Subarachnoid Hemorrhage
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+95%
Common Side Effects
Post-operative stroke/ischemia
+10%
Intracranial hematoma/hemorrhage
+3%
Infection (meningitis, wound)
+3%
Seizures
+7%
Cranial nerve palsy
+10%
Hydrocephalus
+15%
Cognitive deficits
+10%
Sources:
Active Clinical Trials
4 active trials recruiting for Surgical Clipping in Subarachnoid Hemorrhage
Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage
NCT04785976RECRUITING
5K participants
OBSERVATIONAL
Beijing, China +1 more
Started: Apr 1, 2012
Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
NCT06457347NOT YET RECRUITINGNA
100 participants
INTERVENTIONAL
Started: Jul 1, 2024
International Subarachnoid Aneurysm Trial II
NCT01668563ACTIVE NOT RECRUITINGNA
1.72K participants
INTERVENTIONAL
The Bronx, United States +5 more
Started: Nov 12, 2012
Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
NCT06138353RECRUITINGPHASE2, PHASE3
50 participants
INTERVENTIONAL
Beijing, China
Started: Jan 24, 2024
Completed Clinical Trials
7 completed trials for Surgical Clipping in Subarachnoid Hemorrhage
Early Brain Damage Assessment in Aneurysmal Subarachnoid Haemorrhage in Predicting Cognitive Impairment
NCT06172556COMPLETED
202 participants
OBSERVATIONAL
Shijiazhuang, China
Started: Jan 1, 2021
Brain Aneurysms: Utility of Cisternal Urokinase Irrigation
NCT04792944COMPLETED
247 participants
OBSERVATIONAL
Valencia, Spain
Started: Jan 1, 2007
Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
NCT00558311COMPLETEDPHASE3
1.16K participants
INTERVENTIONAL
Phoenix, United States +116 more
Started: Dec 14, 2007
Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage
NCT02560532COMPLETEDPHASE2
25 participants
INTERVENTIONAL
Helsinki, Finland +10 more
Started: Mar 1, 2016
Enzymatic Evaluation of General Anesthetic Induced Neurotoxicity in Patients With Aneurysmal Subarachnoid Hemorrhage
NCT03213392COMPLETED
32 participants
OBSERVATIONAL
Chandigarh, India
Started: Jan 1, 2016
Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm
NCT03377049COMPLETEDPHASE4
11 participants
INTERVENTIONAL
Madison, United States
Started: Jul 28, 2019
A Study Comparing Modified Lund Concept and Cerebral Perfusion Pressure-targeted Therapy in Secondary Brain Ischaemia.
NCT01206283COMPLETEDNA
60 participants
INTERVENTIONAL
Sarajevo, Bosnia and Herzegovina
Started: Jan 1, 2006