Tranexamic Acid (TXA)
Treatment for Subarachnoid Hemorrhage
Typical Dosage: Loading dose 1g IV, then 1g every 6-8 hours IV
Effectiveness
68%
Safety Score
65%
Clinical Trials
1
Participants
3K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
Loading dose 1g IV, then 1g every 6-8 hours IV
Time to Effect
Immediate
Treatment Duration
24-72 hours (acute)
Evidence Quality
MODERATENumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
75(Treat 75 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$50
Side Effect Mgmt:$100
Total Annual:$250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$70,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$1,250
Tranexamic Acid (TXA) Outcomes
for Subarachnoid Hemorrhage
Efficacy Outcomes
Overall Effectiveness
+68%
Response Rate
+20%
Common Side Effects
Nausea/vomiting
+12%
Diarrhea
+7%
Thrombotic events (DVT/PE)
+3%
Seizures
+0.5%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Tranexamic Acid (TXA) in Subarachnoid Hemorrhage
Ultra-early Tranexamic Acid After Subarachnoid Hemorrhage.
NCT02684812COMPLETEDPHASE2, PHASE3
955 participants
INTERVENTIONAL
Amsterdam, Netherlands
Started: Jul 16, 2012