DFDA

Aqueous Crystalline Penicillin G

Treatment for Syphilis

Typical Dosage: 18-24 million units/day (3-4 million units IV every 4 hours or continuous infusion)

Effectiveness
95%
Safety Score
68%
Clinical Trials
300
Participants
30K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
68
DangerousModerateSafe
Treatment Details
Dosage Range
18-24 million units/day (3-4 million units IV every 4 hours or continuous infusion)
Time to Effect
1-2 weeks for CSF response
Treatment Duration
10-14 days IV
Evidence Quality
HIGH
Number Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,000
Monitoring:$20,000
Side Effect Mgmt:$350
Total Annual:$21,350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$20,000/QALY
QALYs Gained
3
Outcome-Based Costs
Cost per Responder
$23,722
Cost per Remission
$23,722
Aqueous Crystalline Penicillin G Outcomes

for Syphilis

Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Jarisch-Herxheimer reaction
+20%
Hypersensitivity/Allergic reaction (mild)
+8%
Phlebitis at IV site
+7%
Hypersensitivity/Allergic reaction (severe/anaphylaxis)
+1%

Sources:

cdc.gov
whatcomcounty.org
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Aqueous Crystalline Penicillin G in Syphilis

Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis

NCT07904533NOT YET RECRUITINGPHASE3
View Study
778 participants
INTERVENTIONAL
Beijing, China
Started: Nov 15, 2026