DFDA

Ceftriaxone

Treatment for Syphilis

Typical Dosage: 1-2 g IM/IV

Effectiveness
92%
Safety Score
70%
Clinical Trials
3
Participants
40K

Comparative Safety Scale(Higher is safer)

Cyanide☠ī¸
Meth💀
CigarettesđŸšŦ
Chemoâ˜ĸī¸
AlcoholđŸē
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
1-2 g IM/IV
Time to Effect
1-2 weeks for serologic response
Treatment Duration
Single dose or 10-14 days
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$200
Side Effect Mgmt:$35
Total Annual:$435
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$15,000/QALY
QALYs Gained
2.2
Outcome-Based Costs
Cost per Responder
$483
Cost per Remission
$483
Prescription Access Economics
Physician Visit Cost
$300/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$200/year
Risk Assessment
Misuse Risk
MODERATE
Missed Diagnosis Risk
HIGH
Requires Monitoring
Yes
Needs lab work/checkups
Ceftriaxone Outcomes

for Syphilis

Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Injection site pain
+15%
Gastrointestinal upset (diarrhea, nausea)
+7%
Allergic reactions
+3%

Sources:

researchgate.net
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Ceftriaxone in Syphilis

Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy

NCT07207876RECRUITING
View Study
110 participants
OBSERVATIONAL
Los Angeles, United States +8 more
Started: Feb 16, 2026
Completed Clinical Trials
1 completed trial for Ceftriaxone in Syphilis

A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals

NCT00000648COMPLETEDNA
View Study
100 participants
INTERVENTIONAL
Birmingham, United States +41 more