Procaine Penicillin G + Probenecid
Treatment for Syphilis
Typical Dosage: Procaine Penicillin G 2.4 million units IM daily + Probenecid 500 mg orally four times daily
Effectiveness
88%
Safety Score
65%
Clinical Trials
1
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
Procaine Penicillin G 2.4 million units IM daily + Probenecid 500 mg orally four times daily
Time to Effect
2-4 weeks for CSF response
Treatment Duration
10-14 days
Evidence Quality
MODERATENumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
20(Treat 20 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$10,000
Side Effect Mgmt:$200
Total Annual:$10,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
2.5
Outcome-Based Costs
Cost per Responder
$12,471
Cost per Remission
$12,471
Procaine Penicillin G + Probenecid Outcomes
for Syphilis
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Remission Rate
+85%
Common Side Effects
Pain at injection site (Procaine Penicillin G)
+95%
Jarisch-Herxheimer reaction
+20%
Probenecid: Nausea, vomiting, rash
+10%
Hypersensitivity/Allergic reaction (mild)
+8%
Hypersensitivity/Allergic reaction (severe/anaphylaxis)
+1%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Procaine Penicillin G + Probenecid in Syphilis
Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy
NCT05309928COMPLETEDPHASE1
13 participants
INTERVENTIONAL
Birmingham, United States
Started: Aug 29, 2023