DFDA

Acetaminophen

Treatment for Tension Headache

Typical Dosage: 500-1000 mg every 4-6 hours, max 4000 mg/day

Effectiveness
60%
Safety Score
80%
Clinical Trials
2
Participants
65K

Comparative Safety Scale(Higher is safer)

Cyanide☠ī¸
Meth💀
CigarettesđŸšŦ
Chemoâ˜ĸī¸
AlcoholđŸē
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
500-1000 mg every 4-6 hours, max 4000 mg/day
Time to Effect
30-60 minutes
Treatment Duration
As needed for acute episodes
Evidence Quality
HIGH
Number Needed to Treat (NNT)
10(Treat 10 patients to see 1 additional successful outcome)
Confidence Score
83%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$25
Monitoring:$1,000
Side Effect Mgmt:$0
Total Annual:$1,025
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.02
Outcome-Based Costs
Cost per Responder
$45.45
Acetaminophen Outcomes

for Tension Headache

Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+55%

Sources:

cochranelibrary.com
tandfonline.com
tandfonline.com

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
1 active trial recruiting for Acetaminophen in Tension Headache

High- vs Standard-Dose Intravenous Magnesium for Acute Headache

NCT07779486RECRUITINGNA
View Study
300 participants
INTERVENTIONAL
Monastir, Tunisia
Started: Jun 1, 2026