Aspirin + Acetaminophen + Caffeine (Combination)
Treatment for Tension Headache
Typical Dosage: 2 tablets (250mg Aspirin, 250mg Acetaminophen, 65mg Caffeine) every 4-6 hours, max 8 tablets/day
Effectiveness
72%
Safety Score
72%
Clinical Trials
150
Participants
18K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe
Treatment Details
Dosage Range
2 tablets (250mg Aspirin, 250mg Acetaminophen, 65mg Caffeine) every 4-6 hours, max 8 tablets/day
Time to Effect
15-45 minutes
Treatment Duration
As needed for acute episodes (avoid overuse >2-3 days/week)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$1,000
Side Effect Mgmt:$20
Total Annual:$1,070
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$93.33
Aspirin + Acetaminophen + Caffeine (Combination) Outcomes
for Tension Headache
Efficacy Outcomes
Overall Effectiveness
+72%
Response Rate
+75%
Common Side Effects
Nausea
+8%
Dyspepsia
+7%
Nervousness/Insomnia
+10%
Rebound Headache (with overuse)
+15%
Sources:
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov