External Beam Radiation Therapy (EBRT)
Treatment for Thyroid Cancer
Typical Dosage: 40-70 Gy in 1.8-2 Gy fractions
Effectiveness
55%
Safety Score
25%
Clinical Trials
9
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
40-70 Gy in 1.8-2 Gy fractions
Time to Effect
Weeks to months for tumor control
Treatment Duration
5-7 weeks (daily sessions)
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,500
Side Effect Mgmt:$1,000
Total Annual:$2,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$100,000/QALY
QALYs Gained
1
Comparison vs Best Supportive Care
Cost Difference
+$50,000/year
More expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
No dominance
External Beam Radiation Therapy (EBRT) Outcomes
for Thyroid Cancer
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+65%
Remission Rate
+10%
Common Side Effects
Skin redness/irritation
+70%
Dysphagia/sore throat
+40%
Fatigue
+40%
Hoarseness
+20%
Hypothyroidism (long-term)
+10%
Sources:
Active Clinical Trials
4 active trials recruiting for External Beam Radiation Therapy (EBRT) in Thyroid Cancer
Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
NCT04892303RECRUITINGPHASE1
48 participants
INTERVENTIONAL
Baltimore, United States
Started: Mar 17, 2021
RW Study of Adjuvant Radiotherapy in Locally Advanced Thyroid Cancer
NCT06524167RECRUITING
80 participants
OBSERVATIONAL
Shanghai, China
Started: Jul 2, 2024
Adjuvant Radiotherapy in High Risk Locally Advanced DTC
NCT06558981RECRUITINGPHASE3
124 participants
INTERVENTIONAL
Shanghai, China
Started: Jul 11, 2024
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
NCT02713269ACTIVE NOT RECRUITINGPHASE2
60 participants
INTERVENTIONAL
Houston, United States
Started: Aug 29, 2016
Completed Clinical Trials
4 completed trials for External Beam Radiation Therapy (EBRT) in Thyroid Cancer
Multicenter Study Differentiated Thyroid Carcinoma
NCT00144079COMPLETEDPHASE3
500 participants
INTERVENTIONAL
Linz, Austria +9 more
Started: Jan 1, 2000
Nexavar for Neoadjuvant Treatment of Anaplastic Thyroid Cancer
NCT03565536COMPLETEDPHASE2
18 participants
INTERVENTIONAL
Fuzhou, China
Started: May 1, 2018
Study of External Beam Radiotherapy to Thyroid Carcinoma
NCT01173289COMPLETEDPHASE2
62 participants
INTERVENTIONAL
Goyang-si, South Korea
Started: Dec 1, 2009
Clinical Efficacy of 125I Seed Implantation in the Treatment of Refractory Differentiated Thyroid Cancer
NCT06362772COMPLETED
36 participants
OBSERVATIONAL
Started: Jan 1, 2015