Radioactive Iodine-131 (I-131) Therapy
Treatment for Thyroid Cancer
Typical Dosage: 30-200 mCi
Effectiveness
90%
Safety Score
30%
Clinical Trials
14
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
30-200 mCi
Time to Effect
Weeks to months for ablation, sustained effect
Treatment Duration
Single dose or few doses
Evidence Quality
HIGHNumber Needed to Treat (NNT)
18(Treat 18 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,500
Side Effect Mgmt:$300
Total Annual:$1,800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$26,012/QALY
QALYs Gained
2
Comparison vs Observation (no RAI after surgery for intermediate-high risk)
Cost Difference
+$10,000/year
More expensive
QALY Difference
+0.50 QALYs
Better outcomes
Dominance
No dominance
Radioactive Iodine-131 (I-131) Therapy Outcomes
for Thyroid Cancer
Active Clinical Trials
5 active trials recruiting for Radioactive Iodine-131 (I-131) Therapy in Thyroid Cancer
Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer
NCT05468554NOT YET RECRUITINGPHASE3
160 participants
INTERVENTIONAL
Bialystok, Poland
Started: Nov 1, 2022
Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma
NCT04354324RECRUITINGNA
254 participants
INTERVENTIONAL
Guangzhou, China
Started: Apr 20, 2020
Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation
NCT06440850RECRUITINGPHASE2
21 participants
INTERVENTIONAL
Duarte, United States
Started: Jul 15, 2024
The Role of Trop2 in Radioactive Iodine-131 Therapy Sensitivity in Papillary Thyroid Carcinoma
NCT07314255ACTIVE NOT RECRUITING
60 participants
OBSERVATIONAL
Nanchang, China
Started: Dec 18, 2025
Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer
NCT06980103RECRUITINGNA
408 participants
INTERVENTIONAL
Washington D.C., United States +2 more
Started: Aug 6, 2025
Completed Clinical Trials
4 completed trials for Radioactive Iodine-131 (I-131) Therapy in Thyroid Cancer
Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer
NCT02393690COMPLETEDPHASE2
60 participants
INTERVENTIONAL
La Jolla, United States +10 more
Started: May 4, 2015
Iodine I 131 and Pazopanib Hydrochloride in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer Previously Treated With Iodine I 131 That Cannot Be Removed By Surgery
NCT01413113COMPLETEDPHASE1
6 participants
INTERVENTIONAL
Seattle, United States
Started: Dec 1, 2011
Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131
NCT00085293COMPLETEDPHASE2
12 participants
INTERVENTIONAL
Aurora, United States +2 more
Started: May 1, 2004
Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine
NCT00559949COMPLETEDPHASE2
39 participants
INTERVENTIONAL
Tampa, United States +5 more
Started: Dec 1, 2007