Azithromycin
Treatment for Typhoid Fever
Typical Dosage: 500mg orally once daily for 7 days
Effectiveness
90%
Safety Score
70%
Clinical Trials
4
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanideâ ī¸
Methđ
CigarettesđŦ
Chemoâĸī¸
Alcoholđē
Morphineđ
Antibioticsđ
Tylenolđ
Exerciseđ
Waterđ§
70
DangerousModerateSafe
Treatment Details
Dosage Range
500mg orally once daily for 7 days
Time to Effect
3-5 days
Treatment Duration
7-14 days
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$200
Side Effect Mgmt:$20
Total Annual:$235
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$2,938/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$261
Cost per Remission
$276
Prescription Access Economics
Risk Assessment
Requires Monitoring
YesNeeds lab work/checkups
Azithromycin Outcomes
for Typhoid Fever
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Diarrhea
+8%
Nausea
+5%
Abdominal pain
+3%
Vomiting
+2%
Active Clinical Trials
2 active trials recruiting for Azithromycin in Typhoid Fever
Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever
NCT07314281RECRUITINGPHASE4
40 participants
INTERVENTIONAL
Karachi, Pakistan
Started: Apr 22, 2025
COMPARISON OF SINGLE VERSUS COMBINATION DRUG THERAPY IN EXTENSIVELY DRUG RESISTANT SALMONELLA TYPHI IN TERMS OF TIME TO DEFERVESCENCE
NCT07641348NOT YET RECRUITINGNA
94 participants
INTERVENTIONAL
Lahore, Pakistan
Started: Jul 1, 2026
Completed Clinical Trials
4 completed trials for Azithromycin in Typhoid Fever
The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)
NCT04349826COMPLETEDPHASE4
2.15K participants
INTERVENTIONAL
Lalitpur, Nepal
Started: May 23, 2021
Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children
NCT04154722COMPLETEDPHASE4
126 participants
INTERVENTIONAL
Karachi, Pakistan
Started: Jun 20, 2019
This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever
NCT07445282COMPLETEDPHASE4
90 participants
INTERVENTIONAL
Rahim Yar Khan, Pakistan
Started: May 14, 2025
Nepal Undifferentiated Febrile Illness Trial
NCT02773407COMPLETEDPHASE3
330 participants
INTERVENTIONAL
Kathmandu, Nepal +1 more
Started: May 23, 2016