Azathioprine
Treatment for Ulcerative Colitis
Typical Dosage: 2-2.5 mg/kg/day
Effectiveness
60%
Safety Score
30%
Clinical Trials
29
Participants
15K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
2-2.5 mg/kg/day
Time to Effect
3-6 months
Treatment Duration
Long-term
Evidence Quality
MODERATENumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$3,000
Cost per Remission
$5,000
Comparison vs Corticosteroids (maintenance)
Cost Difference
$-1,000/year
Less expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Azathioprine Outcomes
for Ulcerative Colitis
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+50%
Remission Rate
+30%
Common Side Effects
Nausea/Vomiting
+12%
Fatigue
+8%
Pancreatitis
+5%
Leukopenia/Myelosuppression
+3%
Hepatotoxicity
+2%
Sources:
Active Clinical Trials
5 active trials recruiting for Azathioprine in Ulcerative Colitis
Beneficial Effect of Silymarin in Ulcerative Colitis
NCT06213857RECRUITINGPHASE2
44 participants
INTERVENTIONAL
Asyut, Egypt +1 more
Started: Feb 1, 2025
Effectiveness of Ozanimod in Patients With Steroid-Dependent Ulcerative Colitis
NCT07271069NOT YET RECRUITING
150 participants
OBSERVATIONAL
Hokkaidō, Japan
Started: Feb 28, 2026
Efficacy of Top-down Therapy With Mirikizumab Versus Standard of Care With Azathioprine in Patients With Newly Diagnosed Moderate-to-severe Ulcerative Colitis
NCT07235904RECRUITINGPHASE4
300 participants
INTERVENTIONAL
Kiel, Germany
Started: Dec 5, 2025
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants
NCT06126835ACTIVE NOT RECRUITING
2.83K participants
OBSERVATIONAL
Eden Prairie, United States
Started: Aug 26, 2024
Determination of the Optimal Treatment Target in Ulcerative Colitis
NCT04259138ACTIVE NOT RECRUITINGPHASE4
672 participants
INTERVENTIONAL
Ypsilanti, United States +57 more
Started: Feb 18, 2020
Completed Clinical Trials
7 completed trials for Azathioprine in Ulcerative Colitis
A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
NCT02425852COMPLETEDPHASE4
65 participants
INTERVENTIONAL
Besançon, France +15 more
Started: Dec 1, 2016
Granulocyte-monocyte Apheresis in Ulcerative Colitis
NCT03189888COMPLETEDNA
33 participants
INTERVENTIONAL
Started: Jan 1, 2013
Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis
NCT03760003COMPLETEDPHASE2
355 participants
INTERVENTIONAL
San Diego, United States +129 more
Started: Aug 13, 2019
Predicting Response to Standardized Pediatric Colitis Therapy
NCT01536535COMPLETEDPHASE4
431 participants
INTERVENTIONAL
Los Angeles, United States +28 more
Started: Jul 10, 2012
Cost-effectiveness of TPMT Pharmacogenetics
NCT00521950COMPLETEDNA
853 participants
INTERVENTIONAL
Nijmegen, Netherlands +2 more
Started: Sep 1, 2007
An Investigational Study to Test Usability of the Electronic Dosing Equipment Medicpen
NCT00917514COMPLETED
25 participants
OBSERVATIONAL
Huddinge, Sweden
Started: Jun 1, 2009
Prevalence of Cytomegalovirus Infection in Patients With Quiescent Ulcerative Colitis
NCT02684734COMPLETED
50 participants
OBSERVATIONAL
Vancouver, Canada
Started: Dec 1, 2015
Showing 20 of 31 total trials