DFDA

Dextromethorphan

Treatment for Upper Respiratory Infections

Typical Dosage: 10-30mg every 4-8 hours (max 120mg/day)

Effectiveness
65%
Safety Score
75%
Clinical Trials
6
Participants
12K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
10-30mg every 4-8 hours (max 120mg/day)
Time to Effect
15-30 minutes
Treatment Duration
As needed, 3-7 days for cough
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
9(Treat 9 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1500(Treat 1500 patients to see 1 additional serious adverse event)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$10
Monitoring:$600
Side Effect Mgmt:$0
Total Annual:$610
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.003
Outcome-Based Costs
Cost per Responder
$15.38
Dextromethorphan Outcomes

for Upper Respiratory Infections

Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+65%
Common Side Effects
Drowsiness/dizziness
+8%
Nausea
+3%

Sources:

emedinexus.com
bmj.com
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
5 completed trials for Dextromethorphan in Upper Respiratory Infections

A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin

NCT06716645COMPLETEDPHASE4
View Study
244 participants
INTERVENTIONAL
New York, United States
Started: Dec 4, 2024

Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep

NCT00127686COMPLETEDPHASE1
View Study
105 participants
INTERVENTIONAL
Hershey, United States
Started: Sep 1, 2005

To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

NCT03415243COMPLETEDPHASE1
View Study
28 participants
INTERVENTIONAL
Lexington, United States
Started: Mar 1, 2018

The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.

NCT02246166COMPLETEDPHASE4
View Study
53 participants
INTERVENTIONAL
Shanghai, China +1 more
Started: Jan 1, 2015

A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms

NCT03213353COMPLETEDPHASE1
View Study
72 participants
INTERVENTIONAL
Saint Petersburg, Russia
Started: Jul 3, 2017