Saline Nasal Irrigation
Treatment for Upper Respiratory Infections
Typical Dosage: 1-2 washes per nostril, 1-3 times daily
Effectiveness
60%
Safety Score
95%
Clinical Trials
11
Participants
5.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
1-2 washes per nostril, 1-3 times daily
Time to Effect
Immediate
Treatment Duration
As needed, 3-7 days for nasal symptoms
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$600
Side Effect Mgmt:$0
Total Annual:$615
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.004
Outcome-Based Costs
Cost per Responder
$21.43
Saline Nasal Irrigation Outcomes
for Upper Respiratory Infections
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+70%
Common Side Effects
Nasal discomfort/burning
+8%
Ear fullness
+0.5%
Active Clinical Trials
3 active trials recruiting for Saline Nasal Irrigation in Upper Respiratory Infections
Observational Study of RHINOSEDAL in Acute Nasal Obstruction
NCT07620522NOT YET RECRUITING
126 participants
OBSERVATIONAL
Multiple Locations, France
Started: Oct 15, 2026
Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT
NCT07598188NOT YET RECRUITINGNA
60 participants
INTERVENTIONAL
Islamabad, Pakistan
Started: Jul 10, 2026
A COMBINATION OF RECTAL INDOMETHACIN AND COLD WATER EXPOSURE OF THE AMPULLA AFTER ERCP IS SUPERIOR TO RECTAL INDOMETHACIN ALONE IN REDUCING THE INCIDENCE OF POST-ERCP PANCREATITIS -RCT
NCT07574970RECRUITING
150 participants
OBSERVATIONAL
Hyderabad, India
Started: Dec 1, 2025
Completed Clinical Trials
9 completed trials for Saline Nasal Irrigation in Upper Respiratory Infections
Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.
NCT02438579COMPLETEDNA
66 participants
INTERVENTIONAL
Edinburgh, United Kingdom
Started: Aug 1, 2014
Examination of the Effectiveness of Nasal Irrigation Techniques in Infants With Nasal Congestion
NCT06002594COMPLETEDNA
80 participants
INTERVENTIONAL
Istanbul, Turkey (Türkiye)
Started: Aug 15, 2019
Prevention With Healsea in Adults Against Respiratory Infection Study
NCT06613906COMPLETEDNA
198 participants
INTERVENTIONAL
Sofia, Bulgaria
Started: Nov 29, 2024
Testing the Efficacy in Adults With Cold of HEalsea Rescue*
NCT05819190COMPLETEDNA
200 participants
INTERVENTIONAL
Sofia, Bulgaria
Started: Dec 14, 2022
HEALSea Nasal Spray for Prevention of Infections in Children
NCT06582589COMPLETEDPHASE2, PHASE3
139 participants
INTERVENTIONAL
Dupnitsa, Bulgaria +7 more
Started: Nov 25, 2024
Pain Reduction Using Two Cold Irrigating Protocols in Teeth With Vital Pulps.
NCT03559127COMPLETEDNA
240 participants
INTERVENTIONAL
Tijuana, Mexico +2 more
Started: Mar 7, 2018
Impact of Intracanal Cryotherapy and Corticosteroids on Post Endodontic Pain
NCT07676396COMPLETEDPHASE4
40 participants
INTERVENTIONAL
Giza, Egypt
Started: Apr 1, 2025
The Effect of Different Intraradicular Cryotherapy on Post-operative Pain and the Level of Substance P
NCT06106386COMPLETEDNA
135 participants
INTERVENTIONAL
Cairo, Egypt
Started: Jan 1, 2024
Coblation Tonsillotomy Versus Radiofrequency and Cold Knife Dissection Tonsillectomy
NCT06937762COMPLETEDNA
72 participants
INTERVENTIONAL
Kafrelsheikh, Egypt
Started: Apr 20, 2025