Fosfomycin
Treatment for Urinary Tract Infection
Typical Dosage: 3g single dose
Effectiveness
85%
Safety Score
72%
Clinical Trials
36
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe
Treatment Details
Dosage Range
3g single dose
Time to Effect
1-2 days
Treatment Duration
Single dose
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
89%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$160
Side Effect Mgmt:$10
Total Annual:$220
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.005
Outcome-Based Costs
Cost per Responder
$250
Cost per Remission
$268.29
Prescription Access Economics
Annual Societal Loss per Patient
$-445
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$120/year
Time Cost
$60/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$50/year
Potential OTC Price
$15/year
Estimated if OTC available
Early Treatment Benefit
+0.00 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATEMissed Diagnosis Risk
MODERATEFosfomycin Outcomes
for Urinary Tract Infection
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+88%
Remission Rate
+82%
Common Side Effects
Diarrhea
+9%
Nausea
+6%
Headache
+4%
Active Clinical Trials
3 active trials recruiting for Fosfomycin in Urinary Tract Infection
Fosfomycin Versus Standard of Care in Children With Antibiotic-resistant Urinary Tract Infections
NCT05709028RECRUITINGPHASE3
300 participants
INTERVENTIONAL
Sydney, Australia +4 more
Started: Aug 2, 2023
COMPARISON OF NITROFURANTOIN WITH FOSFOMYCIN in TREATING CYSTITIS IN WOMEN
NCT06518291NOT YET RECRUITINGPHASE4
392 participants
INTERVENTIONAL
Started: Jan 1, 2025
FOsfomycin for Male Urinary Tract Infection
NCT06822751NOT YET RECRUITINGPHASE3
138 participants
INTERVENTIONAL
Started: Jun 1, 2025
Completed Clinical Trials
11 completed trials for Fosfomycin in Urinary Tract Infection
Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.
NCT04959331COMPLETEDPHASE4
1K participants
INTERVENTIONAL
Calatayud, Spain +32 more
Started: Nov 2, 2021
Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial
NCT03151603COMPLETEDPHASE4
398 participants
INTERVENTIONAL
Achim, Germany +46 more
Started: May 3, 2017
Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI
NCT01488955COMPLETEDPHASE4
494 participants
INTERVENTIONAL
Göttingen, Germany +1 more
Started: Feb 1, 2012
Observational Follow-up Study of REGATTA
NCT03176563COMPLETED
398 participants
OBSERVATIONAL
Achim, Germany +46 more
Started: May 3, 2017
Single Dose Monurol for Treatment of Acute Cystitis
NCT00976963COMPLETEDNA
300 participants
INTERVENTIONAL
Seattle, United States
Started: Sep 17, 2009
Efficacy of CLR Compared to Fosfomycin Trometamol in Acute Lower uUTIs
NCT02639520COMPLETEDPHASE3
659 participants
INTERVENTIONAL
Giessen, Germany
Started: Dec 1, 2015
Clinical Trial of Pivmecillinam Hydrochloride Tablets in the Treatment of Uncomplicated Urinary Tract Infection
NCT05545137COMPLETEDPHASE3
299 participants
INTERVENTIONAL
Beijing, China +9 more
Started: Sep 29, 2022
Effect of Cranberry Extract on the Urinary System
NCT05260554COMPLETED
2 participants
OBSERVATIONAL
Kırklareli, Turkey (Türkiye)
Started: Jan 26, 2022
Efficacy Study of Prophylaxis With Fosfomycin Versus Ciprofloxacin Prior Prostate Biopsy
NCT01803191COMPLETEDPHASE4
461 participants
INTERVENTIONAL
Cartagena, Spain +2 more
Started: Aug 1, 2012
Efficacy of Collagen, Propolis Plus Quercetin (Proqutin®), Bacillus Coagulans, Hyaluronic Acid and Chondroitin Sulphate and D-Mannose to Avoid Symptoms and Prevents Recurrence in Women With Recurrent Urinary Tract Infections
NCT06659016COMPLETEDPHASE4
148 participants
INTERVENTIONAL
Napoli, Italy
Started: Feb 1, 2023
Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients
NCT03235947COMPLETEDPHASE4
82 participants
INTERVENTIONAL
Mexico City, Mexico
Started: Sep 7, 2016
Showing 20 of 37 total trials