Trimethoprim/Sulfamethoxazole
Treatment for Urinary Tract Infection
Typical Dosage: 160mg/800mg twice daily
Effectiveness
82%
Safety Score
68%
Clinical Trials
43
Participants
60K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
160mg/800mg twice daily
Time to Effect
1-2 days
Treatment Duration
3-7 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
9(Treat 9 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$160
Side Effect Mgmt:$10
Total Annual:$185
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.004
Outcome-Based Costs
Cost per Responder
$217.65
Cost per Remission
$231.25
Trimethoprim/Sulfamethoxazole Outcomes
for Urinary Tract Infection
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Nausea
+12%
Rash
+8%
Diarrhea
+7%
Photosensitivity
+3%
Sources:
Active Clinical Trials
1 active trial recruiting for Trimethoprim/Sulfamethoxazole in Urinary Tract Infection
A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)
NCT05488340RECRUITINGPHASE2
318 participants
INTERVENTIONAL
Fresno, United States +11 more
Started: Jul 13, 2022
Completed Clinical Trials
13 completed trials for Trimethoprim/Sulfamethoxazole in Urinary Tract Infection
D Mannose in Recurrent Urinary Tract Infections
NCT01808755COMPLETEDPHASE3
60 participants
INTERVENTIONAL
Pavia, Italy
Started: Jan 1, 2012
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
NCT00405704COMPLETEDPHASE3
607 participants
INTERVENTIONAL
Birmingham, United States +18 more
Started: May 1, 2007
The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children"
NCT01595529COMPLETEDPHASE2
717 participants
INTERVENTIONAL
Pittsburgh, United States
Started: May 18, 2012
Prophylactic Antibiotics on Urethral Catheter Withdrawal
NCT00126698COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Nieuwegein, Netherlands
Started: Jan 1, 2005
Single Dose Monurol for Treatment of Acute Cystitis
NCT00976963COMPLETEDNA
300 participants
INTERVENTIONAL
Seattle, United States
Started: Sep 17, 2009
A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux
NCT00382343COMPLETEDPHASE4
96 participants
INTERVENTIONAL
Bologna, Italy +6 more
Started: Nov 1, 1999
Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients
NCT03235947COMPLETEDPHASE4
82 participants
INTERVENTIONAL
Mexico City, Mexico
Started: Sep 7, 2016
Efficacy of Fosfomycin-Trometamol in Urinary Tract Infection Prophylaxis After Kidney Transplantation
NCT01820897COMPLETEDPHASE4
130 participants
INTERVENTIONAL
Mexico City, Mexico +1 more
Started: Apr 1, 2013
Seven vs. 14 Days Treatment for Male Urinary Tract Infection
NCT01994538COMPLETEDNA
273 participants
INTERVENTIONAL
Minneapolis, United States +1 more
Started: Apr 24, 2014
Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy
NCT04502095COMPLETEDPHASE4
89 participants
INTERVENTIONAL
Buffalo, United States
Started: Sep 2, 2020
Short Course Nitrofurantoin for Acute Cystitis
NCT00391651COMPLETEDPHASE2
338 participants
INTERVENTIONAL
Seattle, United States
Started: Jan 1, 2002
Fluoroquinolone Associated Disability
NCT03535558COMPLETED
239K participants
OBSERVATIONAL
Titusville, United States
Started: May 17, 2018
Usefulness of Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux.
NCT00200616COMPLETEDNA
232 participants
INTERVENTIONAL
Nantes, France
Started: Apr 1, 2001
Showing 20 of 44 total trials