DFDA

Trimethoprim-sulfamethoxazole (TMP-SMX)

Treatment for Urinary Tract Infections And Interstitial Nephritis

Typical Dosage: 160mg/800mg (DS) twice daily

Effectiveness
88%
Safety Score
70%
Clinical Trials
1
Participants
60K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
160mg/800mg (DS) twice daily
Time to Effect
1-2 days
Treatment Duration
3 days
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$600
Side Effect Mgmt:$5
Total Annual:$620
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
Outcome-Based Costs
Cost per Responder
$24
Cost per Remission
$25
Prescription Access Economics
Annual Societal Loss per Patient
$130
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$150/year
Time Cost
$50/year
Travel + wait time
Insurance Admin Cost
$15/year
Prior auth, claims
Rx Price
$15/year
Potential OTC Price
$7/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
MODERATE
Trimethoprim-sulfamethoxazole (TMP-SMX) Outcomes

for Urinary Tract Infections And Interstitial Nephritis

Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Nausea/vomiting
+8%
Skin rash
+4%
Diarrhea
+3%

Sources:

researchgate.net
idsociety.org
oup.com

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Trimethoprim-sulfamethoxazole (TMP-SMX) in Urinary Tract Infections And Interstitial Nephritis

A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux

NCT00382343COMPLETEDPHASE4
View Study
96 participants
INTERVENTIONAL
Bologna, Italy +6 more
Started: Nov 1, 1999