Percutaneous Nephrolithotomy (PCNL)
Treatment for Urolithiasis
Effectiveness
95%
Safety Score
52%
Clinical Trials
81
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
52
DangerousModerateSafe
Treatment Details
Time to Effect
Immediate stone removal, recovery weeks
Treatment Duration
Single procedure, hospital stay 1-3 days
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,500
Side Effect Mgmt:$1,000
Total Annual:$17,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$18,421
Cost per Remission
$18,421
Percutaneous Nephrolithotomy (PCNL) Outcomes
for Urolithiasis
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Hemorrhage requiring transfusion
+5%
Infection/Sepsis
+8%
Fever
+15%
Organ injury (e.g., colon, pleura)
+1%
Prolonged pain
+10%
Sources:
Active Clinical Trials
8 active trials recruiting for Percutaneous Nephrolithotomy (PCNL) in Urolithiasis
Safety and Effectiveness of Antegrade Flexible Ureteroscopy-Assisted Percutaneous Nephrolithotomy for Staghorn Calculi
NCT07172373NOT YET RECRUITINGNA
420 participants
INTERVENTIONAL
Started: Oct 1, 2025
Feasibility of Radiation-Free Percutaneus Nephrolithotomy for Kidney Stones
NCT06922006ACTIVE NOT RECRUITING
67 participants
OBSERVATIONAL
San Diego, United States
Started: Mar 26, 2024
VISOR Versus PCNL for Treatment of 2-4cm Renal Stones
NCT07159503ENROLLING BY INVITATIONNA
170 participants
INTERVENTIONAL
Hangzhou, China
Started: Apr 20, 2025
High Supracostal Versus Subcostal Puncture in Adult PCNL
NCT06350045ACTIVE NOT RECRUITINGPHASE4
162 participants
INTERVENTIONAL
Asyut, Egypt
Started: Mar 1, 2024
Three Dimensional Virtual Reconstruction (3D) in Percutaneous Nephrolithotomy
NCT06797466RECRUITINGNA
100 participants
INTERVENTIONAL
Adıyaman, Turkey (Türkiye)
Started: Jan 21, 2025
F-URS and Mini PCNL for Pediatric Urolithiasis
NCT06571617NOT YET RECRUITINGNA
160 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Sep 10, 2024
FANS-Assisted Mini-PCNL for Complex Renal Stones
NCT07332286RECRUITINGNA
30 participants
INTERVENTIONAL
Guangzhou, China
Started: Dec 19, 2025
Flexible Ureteroscopy With a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for 1-2 cm Lower Pole Kidney Stones
NCT07159035RECRUITINGNA
640 participants
INTERVENTIONAL
Guangzhou, China
Started: Aug 28, 2025
Completed Clinical Trials
8 completed trials for Percutaneous Nephrolithotomy (PCNL) in Urolithiasis
Comparison of Trifecta Analysis of Standard Versus Mini Percutaneous Nephrolithotomy in the Management of Urolithiasis
NCT06836700COMPLETEDNA
180 participants
INTERVENTIONAL
Peshawar, Pakistan
Started: Jan 10, 2022
Tubeless vs Tube PCNL in Pediatric Nephrolithiasis: A Randomized Controlled Trial.
NCT07183930COMPLETEDNA
640 participants
INTERVENTIONAL
Peshawar, Pakistan
Started: Oct 1, 2024
Standard vs Mini-PCNL for the Treatment of Stone Disease
NCT04069013COMPLETEDNA
18 participants
INTERVENTIONAL
Cleveland, United States
Started: May 1, 2022
Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
NCT06526390COMPLETEDNA
720 participants
INTERVENTIONAL
Guangzhou, China
Started: Aug 21, 2024
The Feasibility, Safety, and Efficacy of Not Indwelling of Ureteral Stents in Percutaneous Nephrolithotomy
NCT06455618COMPLETEDNA
80 participants
INTERVENTIONAL
Guangzhou, China
Started: Apr 2, 2023
The Success of Pediatric Percutaneous Nephrolithotomy
NCT04299204COMPLETEDNA
553 participants
INTERVENTIONAL
Started: Jan 15, 1998
Mini-PNCL vs fURS in Management of Nephrolithiasis
NCT04389853COMPLETEDNA
76 participants
INTERVENTIONAL
Thunder Bay, Canada
Started: Oct 5, 2020
Stone Access and Removal (STAR) Study
NCT06330701COMPLETEDNA
15 participants
INTERVENTIONAL
Indianapolis, United States +1 more
Started: Jan 18, 2024
Showing 20 of 86 total trials