Percutaneous Nephrolithotomy (PCNL)
Treatment for Urolithiasis
Effectiveness
95%
Safety Score
52%
Clinical Trials
81
Participants
75K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
52
DangerousModerateSafe
Treatment Details
Time to Effect
Immediate stone removal, recovery weeks
Treatment Duration
Single procedure, hospital stay 1-3 days
Evidence Quality
HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,500
Side Effect Mgmt:$1,000
Total Annual:$17,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$18,421
Cost per Remission
$18,421
Percutaneous Nephrolithotomy (PCNL) Outcomes
for Urolithiasis
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Hemorrhage requiring transfusion
+5%
Infection/Sepsis
+8%
Fever
+15%
Organ injury (e.g., colon, pleura)
+1%
Prolonged pain
+10%
Sources:
Active Clinical Trials
5 active trials recruiting for Percutaneous Nephrolithotomy (PCNL) in Urolithiasis
Supine vs. Prone PCNL for Large Renal Stones: A Randomized Trial in Yemen.
NCT07627503NOT YET RECRUITINGNA
140 participants
INTERVENTIONAL
Sanaa, Yemen
Started: Jun 1, 2026
Safety and Effectiveness of Antegrade Flexible Ureteroscopy-Assisted Percutaneous Nephrolithotomy for Staghorn Calculi
NCT07172373NOT YET RECRUITINGNA
420 participants
INTERVENTIONAL
Started: Oct 1, 2025
Feasibility of Radiation-Free Percutaneus Nephrolithotomy for Kidney Stones
NCT06922006ACTIVE NOT RECRUITING
67 participants
OBSERVATIONAL
San Diego, United States
Started: Mar 26, 2024
PCNL Versus RIRS for Management of Stones in Solitary Kidney
NCT07730892ACTIVE NOT RECRUITINGNA
83 participants
INTERVENTIONAL
Al Mansurah, Egypt
Started: Nov 23, 2024
Metaphylaxis of Infected Kidney Stones After Percutaneous Nephrolithotripsy
NCT07393711NOT YET RECRUITINGNA
95 participants
INTERVENTIONAL
Aqtöbe, Kazakhstan
Started: Mar 1, 2026
Completed Clinical Trials
12 completed trials for Percutaneous Nephrolithotomy (PCNL) in Urolithiasis
IAU Percutaneous Nephrolithotripsy Study
NCT07622238COMPLETED
4K participants
OBSERVATIONAL
Sofia, Bulgaria +1 more
Started: Aug 15, 2019
Comparison of Tubeless Versus Standard Percutaneous Nephrolithotomy (PCNL) for Renal Stones
NCT07522619COMPLETEDNA
60 participants
INTERVENTIONAL
Karachi, Pakistan
Started: Nov 24, 2021
Tubeless vs Tube PCNL in Pediatric Nephrolithiasis
NCT07183930COMPLETEDNA
640 participants
INTERVENTIONAL
Peshawar, Pakistan
Started: Oct 1, 2024
Comparison of Trifecta Analysis of Standard Versus Mini Percutaneous Nephrolithotomy in the Management of Urolithiasis
NCT06836700COMPLETEDNA
180 participants
INTERVENTIONAL
Peshawar, Pakistan
Started: Jan 10, 2022
Standard vs Mini-PCNL for the Treatment of Stone Disease
NCT04069013COMPLETEDNA
18 participants
INTERVENTIONAL
Cleveland, United States
Started: May 1, 2022
Flexible Ureteroscopy With Tip-bendable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2-3cm Renal Stones
NCT06526390COMPLETEDNA
720 participants
INTERVENTIONAL
Guangzhou, China
Started: Aug 21, 2024
Suction Mini-PCNL Versus Standard PCNL for the Management of 2-4cm Kidney Stones
NCT05088213COMPLETEDNA
960 participants
INTERVENTIONAL
Guangzhou, China
Started: Dec 1, 2021
Preoperative Anxiety in Patients Undergoing RIRS and PCNL
NCT07772830COMPLETED
120 participants
OBSERVATIONAL
Samsun, Turkey (Türkiye)
Started: Jan 20, 2024
The Feasibility, Safety, and Efficacy of Not Indwelling of Ureteral Stents in Percutaneous Nephrolithotomy
NCT06455618COMPLETEDNA
80 participants
INTERVENTIONAL
Guangzhou, China
Started: Apr 2, 2023
Which Patinets Benefit More From Percutaneous Nephrolithotomy? A Location-Based Comparative Analysis of PCNL and RIRS for 1-2 cm Renal Stones
NCT07589153COMPLETEDNA
110 participants
INTERVENTIONAL
Started: May 1, 2012
Preoperative Prophylactic Fosfomycin Trometamol Versus 5-day Levofloxacin in Prevention of Postpercutaneous Nephrolithotomy Infectious Complications and Sepsis.
NCT07355907COMPLETEDNA
210 participants
INTERVENTIONAL
Tanta, Egypt
Started: Jan 1, 2023
The Success of Pediatric Percutaneous Nephrolithotomy
NCT04299204COMPLETEDNA
553 participants
INTERVENTIONAL
Started: Jan 15, 1998
Showing 20 of 111 total trials