Potassium Citrate (Prevention)
Treatment for Urolithiasis
Typical Dosage: 20-60 mEq daily in divided doses
Effectiveness
70%
Safety Score
68%
Clinical Trials
3
Participants
8K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
20-60 mEq daily in divided doses
Time to Effect
Weeks to months for optimal urinary parameters, long-term for prevention
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
100(Treat 100 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$350
Monitoring:$300
Side Effect Mgmt:$50
Total Annual:$700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$-25,000/QALY
QALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$1,167
Potassium Citrate (Prevention) Outcomes
for Urolithiasis
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Common Side Effects
Gastrointestinal upset (nausea, diarrhea)
+15%
Hyperkalemia (with renal impairment)
+1%
Stomach discomfort
+10%
Active Clinical Trials
1 active trial recruiting for Potassium Citrate (Prevention) in Urolithiasis
Role of Medication in Making Urine Less Acidic as Part of Kidney Stone Prevention
NCT06819111NOT YET RECRUITINGPHASE1
20 participants
INTERVENTIONAL
Started: Jan 1, 2026
Completed Clinical Trials
1 completed trial for Potassium Citrate (Prevention) in Urolithiasis
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
NCT05365477COMPLETEDPHASE4
56 participants
INTERVENTIONAL
Nashville, United States
Started: Aug 4, 2022