External Beam Radiation Therapy (EBRT)
Treatment for Uterine Cancer
Typical Dosage: 45-50.4 Gy in 1.8-2 Gy fractions
Effectiveness
45%
Safety Score
25%
Clinical Trials
118
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
45-50.4 Gy in 1.8-2 Gy fractions
Time to Effect
Effects accrue during 4-6 week treatment
Treatment Duration
4-6 weeks (daily sessions)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$25,000
Side Effect Mgmt:$5,000
Total Annual:$30,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$110,000/QALY
QALYs Gained
0.3
Comparison vs Observation
Cost Difference
+$30,000/year
More expensive
QALY Difference
+0.30 QALYs
Better outcomes
Dominance
No dominance
Active Clinical Trials
12 active trials recruiting for External Beam Radiation Therapy (EBRT) in Uterine Cancer
PROTECT: On-line Adaptive Proton Therapy for Cervical Cancer
NCT05406856RECRUITINGNA
30 participants
INTERVENTIONAL
Leiden, Netherlands +1 more
Started: May 2, 2022
Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma
NCT05603910RECRUITINGPHASE1
18 participants
INTERVENTIONAL
Miami, United States
Started: Apr 15, 2023
Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study
NCT05857631RECRUITINGNA
90 participants
INTERVENTIONAL
Navi Mumbai, India +1 more
Started: May 29, 2023
Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions
NCT05524389NOT YET RECRUITINGPHASE3
624 participants
INTERVENTIONAL
Started: Dec 1, 2022
A Study to Evaluate the Safety, Tolerability, Preliminary Efficacy of KRC-01
NCT05570422NOT YET RECRUITINGPHASE1
70 participants
INTERVENTIONAL
Chandigarh, India +4 more
Started: Dec 1, 2025
A Study of Nimotuzumab Plus Concurrent Chemoradiotherapy Sequential Maintenance Treatment for Cervical Carcinoma
NCT06333821NOT YET RECRUITINGPHASE3
460 participants
INTERVENTIONAL
Started: Apr 1, 2024
Study of Chemoradiotherapy With Envafolimab For The Treatment of Locally Advanced Cervical Cancer
NCT05799469NOT YET RECRUITINGPHASE2
36 participants
INTERVENTIONAL
Chongqing, China
Started: May 1, 2023
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)
NCT04221945ACTIVE NOT RECRUITINGPHASE3
1.06K participants
INTERVENTIONAL
Phoenix, United States +175 more
Started: May 12, 2020
Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix
NCT03256916ACTIVE NOT RECRUITINGPHASE3
348 participants
INTERVENTIONAL
Mumbai, India
Started: Jan 16, 2018
Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer
NCT04214067ACTIVE NOT RECRUITINGPHASE3
168 participants
INTERVENTIONAL
Birmingham, United States +279 more
Started: Apr 9, 2020
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
NCT02466971ACTIVE NOT RECRUITINGPHASE3
450 participants
INTERVENTIONAL
Birmingham, United States +381 more
Started: May 10, 2016
Induction Immunotherapy Combined With Chemotherapy Followed by Concurrent Chemoradiotherap and Immunotherapy for Cervical Cancer
NCT07092696RECRUITINGPHASE2
34 participants
INTERVENTIONAL
Tianjin, China
Started: Dec 1, 2024
Completed Clinical Trials
3 completed trials for External Beam Radiation Therapy (EBRT) in Uterine Cancer
Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer
NCT00369122COMPLETEDPHASE2
60 participants
INTERVENTIONAL
Burbank, United States +105 more
Started: Aug 11, 2006
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery
NCT01101451COMPLETEDPHASE3
340 participants
INTERVENTIONAL
Anchorage, United States +718 more
Started: Apr 12, 2010
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
NCT00980954COMPLETEDPHASE3
236 participants
INTERVENTIONAL
Birmingham, United States +124 more
Started: Sep 1, 2009
Showing 20 of 122 total trials