Vaginal Brachytherapy
Treatment for Uterine Cancer
Typical Dosage: 21 Gy in 3 fractions or 30 Gy in 5 fractions
Effectiveness
40%
Safety Score
50%
Clinical Trials
64
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
21 Gy in 3 fractions or 30 Gy in 5 fractions
Time to Effect
Treatment course over 1-2 weeks
Treatment Duration
3-5 fractions over 1-2 weeks
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
25(Treat 25 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$10,000
Side Effect Mgmt:$1,000
Total Annual:$11,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$70,000/QALY
QALYs Gained
0.2
Comparison vs External Beam Radiation Therapy
Cost Difference
$-19,000/year
Less expensive
QALY Difference
-0.10 QALYs
Worse outcomes
Dominance
No dominance
Vaginal Brachytherapy Outcomes
for Uterine Cancer
Efficacy Outcomes
Overall Effectiveness
+40%
Common Side Effects
Vaginal dryness
+40%
Vaginal stenosis
+30%
Mild bladder irritation
+15%
Mild bowel irritation
+10%
Sources:
Active Clinical Trials
9 active trials recruiting for Vaginal Brachytherapy in Uterine Cancer
Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
NCT03422198RECRUITINGPHASE3
188 participants
INTERVENTIONAL
Palo Alto, United States +4 more
Started: Feb 2, 2018
Retrospective Study of Brachytherapy
NCT05242861RECRUITING
300 participants
OBSERVATIONAL
Hangzhou, China
Started: Feb 20, 2022
Vaginal Cuff Brachytherapy Fractionation Study
NCT03785288RECRUITINGPHASE3
258 participants
INTERVENTIONAL
Baltimore, United States +2 more
Started: Jan 17, 2019
Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
NCT07121543RECRUITING
20 participants
OBSERVATIONAL
La Jolla, United States
Started: Aug 4, 2025
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features (RAINBO) - NSMP-ORANGE Trial: Comparing Radiotherapy With Oral Progestin Tablets vs. the Current Standard Care, Radiotherapy and Chemotherapy, in Patients With NSMP Endometrial Cancer
NCT07831902RECRUITINGPHASE3
600 participants
INTERVENTIONAL
Bath, United Kingdom +11 more
Started: Jun 29, 2026
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
NCT05640999RECRUITINGPHASE2
393 participants
INTERVENTIONAL
Anchorage, United States +120 more
Started: Dec 19, 2022
The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage I Endometrial Carcinoma
NCT01820858ACTIVE NOT RECRUITINGPHASE3
300 participants
INTERVENTIONAL
Wuhan, China +2 more
Started: Nov 1, 2012
Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study
NCT05857631RECRUITINGNA
90 participants
INTERVENTIONAL
Navi Mumbai, India +1 more
Started: May 29, 2023
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer
NCT03469674ACTIVE NOT RECRUITINGPHASE3
550 participants
INTERVENTIONAL
Vienna, Austria +30 more
Started: Jun 10, 2016
Completed Clinical Trials
7 completed trials for Vaginal Brachytherapy in Uterine Cancer
Magnetic Resonance Imaging Guided Gynecologic Brachytherapy
NCT00112307COMPLETEDNA
15 participants
INTERVENTIONAL
Started: Mar 1, 2003
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Patients With Endometrioid Cancer
NCT00542490COMPLETEDPHASE2
23 participants
INTERVENTIONAL
Oklahoma City, United States
Started: Sep 1, 2007
Feasibility Study Using the Xoft System for the Treatment of Endometrial Cancer
NCT01045187COMPLETEDNA
15 participants
INTERVENTIONAL
Casa Grande, United States +5 more
Started: Oct 1, 2008
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
NCT03189446COMPLETEDPHASE2
39 participants
INTERVENTIONAL
Oklahoma City, United States
Started: Oct 2, 2017
External-Beam Radiation Therapy Compared With Vaginal Brachytherapy After Surgery for Stage I Endometrial Cancer
NCT00376844COMPLETEDPHASE3
427 participants
INTERVENTIONAL
Leiden, Netherlands
Started: May 1, 2002
The Effect of Vaginal Dilator Use
NCT07547267COMPLETEDNA
80 participants
INTERVENTIONAL
Istanbul, Turkey (Türkiye)
Started: Jun 1, 2025
Toxicities of Cervix and Corpus Uteri Carcinomas Treatment and Evaluation of Impact on Sexual Function
NCT01650987COMPLETED
72 participants
OBSERVATIONAL
Lille, France
Started: May 1, 2009
Showing 20 of 72 total trials