Leuprolide (GnRH Agonist)
Treatment for Uterine Fibroids
Typical Dosage: 3.75 mg IM monthly
Effectiveness
80%
Safety Score
55%
Clinical Trials
4
Participants
15K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe
Treatment Details
Dosage Range
3.75 mg IM monthly
Time to Effect
1-2 months
Treatment Duration
3-6 months (pre-surgical) or up to 12 months with add-back therapy
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$2,000
Monitoring:$300
Side Effect Mgmt:$300
Total Annual:$2,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEQALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$3,059
Comparison vs Watchful Waiting
Cost Difference
+$2,600/year
More expensive
QALY Difference
+0.10 QALYs
Better outcomes
Dominance
No dominance
Leuprolide (GnRH Agonist) Outcomes
for Uterine Fibroids
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+85%
Common Side Effects
Hot flashes
+80%
Vaginal dryness
+50%
Mood changes
+30%
Headache
+25%
Decreased bone mineral density (if prolonged)
+10%
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov