Radiofrequency Ablation (RFA)
Treatment for Uterine Fibroids
Effectiveness
80%
Safety Score
60%
Clinical Trials
15
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Time to Effect
1-3 months
Treatment Duration
One-time procedure
Evidence Quality
MODERATEConfidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$500
Side Effect Mgmt:$0
Total Annual:$500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$120,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$15,000
Comparison vs Myomectomy
Cost Difference
$-3,000/year
Less expensive
QALY Difference
-0.10 QALYs
Worse outcomes
Dominance
No dominance
Radiofrequency Ablation (RFA) Outcomes
for Uterine Fibroids
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Common Side Effects
Post-procedure pain
+60%
Cramping
+40%
Vaginal discharge
+8%
Infection
+1%
Sources:
Active Clinical Trials
1 active trial recruiting for Radiofrequency Ablation (RFA) in Uterine Fibroids
Uterine Leiomyoma Treatment With Radiofrequency Ablation (ULTRA) Registry
NCT02100904ACTIVE NOT RECRUITING
578 participants
OBSERVATIONAL
Irvine, United States +11 more
Started: May 1, 2014
Completed Clinical Trials
9 completed trials for Radiofrequency Ablation (RFA) in Uterine Fibroids
Laparoscopic Radiofrequency Ablation (RFA) of Symptomatic Uterine Fibroids
NCT00874029COMPLETEDNA
137 participants
INTERVENTIONAL
Phoenix, United States +10 more
Started: Mar 1, 2009
Uterine Leiomyoma Treatment With Radiofrequency Ablation
NCT01840124COMPLETEDNA
26 participants
INTERVENTIONAL
Davis, United States +4 more
Started: Jul 1, 2013
Post Market TRUST - U.S.A. Study
NCT02163525COMPLETEDNA
114 participants
INTERVENTIONAL
Santa Monica, United States +8 more
Started: Jun 12, 2014
Tailored Radiofrequency Ablation of Uterine Myomas
NCT04091529COMPLETEDNA
54 participants
INTERVENTIONAL
Genoa, Italy
Started: Mar 1, 2017
Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids
NCT02844920COMPLETED
37 participants
OBSERVATIONAL
Mannheim, Germany +5 more
Started: Jul 20, 2017
Laparoscopic Uterine Sparing Techniques Outcomes and Reinterventions
NCT01750008COMPLETEDNA
51 participants
INTERVENTIONAL
Tübingen, Germany
Started: Nov 1, 2012
Post Market TRUST Study
NCT01563783COMPLETEDNA
84 participants
INTERVENTIONAL
Saskatoon, Canada
Started: Dec 1, 2012
Patient Centered Results for Uterine Fibroids
NCT02260752COMPLETED
3.09K participants
OBSERVATIONAL
San Francisco, United States +8 more
Started: Nov 1, 2015
Sonography Guided Transcervical Ablation of Uterine Fibroids
NCT02228174COMPLETEDNA
147 participants
INTERVENTIONAL
Phoenix, United States +22 more
Started: Oct 1, 2014