Valacyclovir
Treatment for Varicella And Herpes Zoster
Typical Dosage: 1000mg three times daily for 7 days
Effectiveness
88%
Safety Score
68%
Clinical Trials
13
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
1000mg three times daily for 7 days
Time to Effect
24-48 hours
Treatment Duration
7 days
Evidence Quality
HIGHNumber Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$40
Monitoring:$100
Side Effect Mgmt:$10
Total Annual:$150
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.04
Outcome-Based Costs
Cost per Responder
$200
Cost per Remission
$167
Comparison vs Acyclovir
Cost Difference
+$10/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Valacyclovir Outcomes
for Varicella And Herpes Zoster
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Remission Rate
+90%
Common Side Effects
Nausea
+15%
Headache
+15%
Abdominal pain
+6%
Diarrhea
+5%
Active Clinical Trials
1 active trial recruiting for Valacyclovir in Varicella And Herpes Zoster
Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation
NCT07515885RECRUITINGNA
228 participants
INTERVENTIONAL
Hangzhou, China
Started: Sep 1, 2025
Completed Clinical Trials
9 completed trials for Valacyclovir in Varicella And Herpes Zoster
A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster
NCT00831103COMPLETEDPHASE2
373 participants
INTERVENTIONAL
Houston, United States
Started: Nov 1, 2007
A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster
NCT05492591COMPLETEDPHASE2
50 participants
INTERVENTIONAL
Nanjing, China
Started: Oct 11, 2022
Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fed Conditions
NCT01132716COMPLETEDNA
48 participants
INTERVENTIONAL
Fargo, United States
Started: Sep 1, 2006
Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fasting Conditions
NCT01132729COMPLETEDNA
48 participants
INTERVENTIONAL
Fargo, United States
Started: Sep 1, 2006
Palatability Testing of a New Paediatric Formulation of Valacyclovir
NCT01682109COMPLETEDPHASE4
41 participants
INTERVENTIONAL
Nijmegen, Netherlands
Started: Sep 1, 2012
Bioequivalence Study in Healthy Volunteers of a New Paediatric Formulation of Valacyclovir
NCT01689285COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Nijmegen, Netherlands
Started: Dec 1, 2013
Reduction of Postherpetic Neuralgia in Herpes Zoster
NCT01250561COMPLETEDNA
133 participants
INTERVENTIONAL
Houston, United States
Started: Feb 1, 2002
A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children
NCT00297206COMPLETEDPHASE1
36 participants
INTERVENTIONAL
Birmingham, United States +12 more
Started: Jan 25, 2003
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
NCT07349680COMPLETEDPHASE3
100 participants
INTERVENTIONAL
Asyut, Egypt
Started: Mar 15, 2023