Endovenous Laser Ablation (EVLA)
Treatment for Varicose Veins
Typical Dosage: Not applicable (procedure)
Effectiveness
92%
Safety Score
70%
Clinical Trials
19
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Not applicable (procedure)
Time to Effect
Days to weeks
Treatment Duration
Single session
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$500
Side Effect Mgmt:$200
Total Annual:$4,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$20,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$4,706
Cost per Remission
$5,000
Comparison vs Venous Stripping and Ligation
Cost Difference
$-4,000/year
Less expensive
QALY Difference
+0.03 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Endovenous Laser Ablation (EVLA) Outcomes
for Varicose Veins
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Pain/discomfort
+60%
Bruising
+50%
Numbness/paresthesia (nerve injury)
+10%
Skin discoloration/hyperpigmentation
+15%
Phlebitis
+8%
Deep Vein Thrombosis (DVT)
+0.5%
Active Clinical Trials
6 active trials recruiting for Endovenous Laser Ablation (EVLA) in Varicose Veins
Endovenous Laser Ablation With 1940 nm Versus 1470 nm
NCT07603570ACTIVE NOT RECRUITINGPHASE3
220 participants
INTERVENTIONAL
Kafr ash Shaykh, Egypt
Started: Sep 1, 2025
Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm)
NCT05663359RECRUITINGNA
280 participants
INTERVENTIONAL
Toulouse, France
Started: Feb 24, 2023
Vacuum-assisted Laser Ablation (VALA) for Treatment of Large Saphenous Veins
NCT06971068RECRUITINGNA
184 participants
INTERVENTIONAL
Minsk, Belarus +8 more
Started: Mar 15, 2025
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
NCT07239284NOT YET RECRUITING
50 participants
OBSERVATIONAL
Started: Dec 10, 2025
The Use of Immersive Virtual Reality as a Method of Treating Anxiety and Procedural Pain During Endovenous Laser Ablation (EVLA) of Lower Varicose Veins Under Tumescent Anesthesia
NCT07624929ENROLLING BY INVITATIONNA
100 participants
INTERVENTIONAL
Bydgoszcz, Poland
Started: Jun 10, 2026
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
NCT07163312NOT YET RECRUITING
50 participants
OBSERVATIONAL
Started: Oct 1, 2025
Completed Clinical Trials
9 completed trials for Endovenous Laser Ablation (EVLA) in Varicose Veins
Clinical Trial of Endovenous 940 and 1470 Laser Ablation for Treating Great Saphenous Veins
NCT01637181COMPLETEDNA
142 participants
INTERVENTIONAL
Rotterdam, Netherlands
Started: May 1, 2012
The Effect of Laser Power and Fiber Traction Speed on the Outcomes of Endovenous Laser Ablation
NCT03037827COMPLETEDNA
203 participants
INTERVENTIONAL
Chelyabinsk, Russia +1 more
Started: Jan 30, 2017
RCT Comparing EVLA Versus Polidocanol Foam in the Treatment of SSV Insufficiency
NCT05468450COMPLETEDNA
161 participants
INTERVENTIONAL
Started: Jul 1, 2015
Flush Versus Standard Distance From Saphenofemoral Junction in Endovenous Laser Ablation of Great Saphenous Vein
NCT06913322COMPLETEDPHASE4
200 participants
INTERVENTIONAL
Kafrelsheikh, Egypt
Started: Jan 21, 2024
Mechanochemical Ablation vs Thermal Ablation
NCT03722134COMPLETEDNA
132 participants
INTERVENTIONAL
Started: Jan 31, 2014
Laser Ablation Versus Mechanochemical Ablation Trial
NCT02627846COMPLETEDPHASE4
150 participants
INTERVENTIONAL
Hull, United Kingdom
Started: Jun 1, 2015
Steam Ablation Versus Endovenous Laser Ablation for the Treatment of Great Saphenous Veins
NCT02046967COMPLETEDNA
237 participants
INTERVENTIONAL
Rotterdam, Netherlands
Started: Nov 1, 2009
Market Penetration of Laser Therapy in Venous Surgery: Ziekenhuis Oost-Limburg - Ziekenhuis Maas En Kempen Center Experience
NCT03856814COMPLETED
500 participants
OBSERVATIONAL
Genk, Belgium
Started: Mar 15, 2019
Treatment of Varicose Veins With the ELVeS® Radial® 2ring Slim Fiber. Are There Limitations?
NCT03810677COMPLETED
150 participants
OBSERVATIONAL
Bonheiden, Belgium +1 more
Started: Apr 15, 2019
Showing 20 of 22 total trials