Radiofrequency Ablation (RFA)
Treatment for Varicose Veins
Typical Dosage: Not applicable (procedure)
Effectiveness
92%
Safety Score
70%
Clinical Trials
39
Participants
28K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Not applicable (procedure)
Time to Effect
Days to weeks
Treatment Duration
Single session
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$500
Side Effect Mgmt:$200
Total Annual:$4,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$22,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$4,706
Cost per Remission
$5,000
Comparison vs Venous Stripping and Ligation
Cost Difference
$-4,000/year
Less expensive
QALY Difference
+0.03 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Radiofrequency Ablation (RFA) Outcomes
for Varicose Veins
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Pain/discomfort
+55%
Bruising
+45%
Numbness/paresthesia (nerve injury)
+8%
Skin discoloration/hyperpigmentation
+12%
Phlebitis
+7%
Deep Vein Thrombosis (DVT)
+0.5%
Active Clinical Trials
3 active trials recruiting for Radiofrequency Ablation (RFA) in Varicose Veins
Calcium Dobesilate After Radiofrequency Ablation for Varicose Veins
NCT07390097NOT YET RECRUITINGPHASE4
250 participants
INTERVENTIONAL
Kozlu, Turkey (Türkiye)
Started: Feb 28, 2026
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
NCT07239284NOT YET RECRUITING
50 participants
OBSERVATIONAL
Started: Dec 10, 2025
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
NCT07163312NOT YET RECRUITING
50 participants
OBSERVATIONAL
Started: Oct 1, 2025
Completed Clinical Trials
9 completed trials for Radiofrequency Ablation (RFA) in Varicose Veins
MOCA Versus RFA in the Treatment of Primary Great Saphenous Varicose Veins
NCT01936168COMPLETEDNA
213 participants
INTERVENTIONAL
Arnhem, Netherlands +4 more
Started: Dec 1, 2016
COMFORT: A Multicenter, Open-label, Randomized, Crossover Study
NCT02462720COMPLETEDPHASE4
35 participants
INTERVENTIONAL
Pensacola, United States +3 more
Started: May 1, 2015
Endovenous Radiofrequency Ablation Closure System in the Treatment of Varicose Veins
NCT04671641COMPLETEDNA
176 participants
INTERVENTIONAL
Shanghai, China +4 more
Started: Mar 24, 2021
Mechanochemical Ablation vs Thermal Ablation
NCT03722134COMPLETEDNA
132 participants
INTERVENTIONAL
Started: Jan 31, 2014
Great Saphenous Vein Sparing Segmental Radiofrequency Ablation in Varicose Veins Patients
NCT05372146COMPLETEDNA
86 participants
INTERVENTIONAL
Moscow, Russia
Started: Nov 1, 2019
Trial of Radiofrequency Thermo-ablation Treatments of Great Saphenous Varicose Veins (3-RF Study)
NCT02441881COMPLETEDNA
182 participants
INTERVENTIONAL
Worcester, United Kingdom
Started: Sep 5, 2014
Endovenous Radiofrequency Versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux
NCT02080013COMPLETEDNA
5 participants
INTERVENTIONAL
Started: Dec 1, 2011
Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence
NCT00621062COMPLETEDNA
540 participants
INTERVENTIONAL
Västerås, Sweden
Started: Jan 1, 2008
Regional Anesthesia and Recovery After Varicose Vein RFA
NCT07514000COMPLETED
40 participants
OBSERVATIONAL
Zonguldak, Turkey (Türkiye)
Started: Jul 1, 2024
Showing 20 of 45 total trials