Oral Cobalamin (Cyanocobalamin/Methylcobalamin)
Treatment for Vitamin B12 Deficiency
Typical Dosage: 1000-2000 mcg daily initially, then 1000 mcg daily for maintenance
Effectiveness
98%
Safety Score
90%
Clinical Trials
11
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe
Treatment Details
Dosage Range
1000-2000 mcg daily initially, then 1000 mcg daily for maintenance
Time to Effect
Hematologic: 5-7 days; Symptomatic: 1-4 weeks; Neurological: Weeks to months
Treatment Duration
Lifetime for chronic deficiency
Evidence Quality
HIGHConfidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$100
Side Effect Mgmt:$5
Total Annual:$135
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$137.76
Cost per Remission
$150
Comparison vs No treatment
Cost Difference
$-135/year
Less expensive
QALY Difference
+0.80 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Active Clinical Trials
2 active trials recruiting for Oral Cobalamin (Cyanocobalamin/Methylcobalamin) in Vitamin B12 Deficiency
A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth
NCT07029698RECRUITINGPHASE4
46 participants
INTERVENTIONAL
Kharkiv, Ukraine +1 more
Started: Apr 16, 2025
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
NCT06966856NOT YET RECRUITINGPHASE3
23 participants
INTERVENTIONAL
Started: Dec 30, 2026
Completed Clinical Trials
8 completed trials for Oral Cobalamin (Cyanocobalamin/Methylcobalamin) in Vitamin B12 Deficiency
Oral/Intramuscular B12 to Treat Cobalamin Deficiency
NCT01476007COMPLETEDNA
284 participants
INTERVENTIONAL
Madrid, Spain
Started: Jul 1, 2014
Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial
NCT01661309COMPLETEDNA
50 participants
INTERVENTIONAL
London, United Kingdom
Started: Mar 1, 2012
Assessing the Efficacy of Different Carrier Systems in Oral Vitamin B12 Supplementation
NCT06376591COMPLETEDNA
70 participants
INTERVENTIONAL
Jamshoro, Pakistan
Started: Apr 12, 2024
Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy
NCT00699478COMPLETEDPHASE2
30 participants
INTERVENTIONAL
Seoul, South Korea
Started: Apr 1, 2008
Efficacy and Safety Study of Oral Eligen® B12 in Subjects With Low Serum Cobalamin
NCT01312831COMPLETEDNA
49 participants
INTERVENTIONAL
Started: Feb 1, 2009
Vitamin B12 Acceptance and Biomarker Response Study
NCT01832129COMPLETEDPHASE4
37 participants
INTERVENTIONAL
Basel, Switzerland
Started: May 1, 2013
A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment
NCT04083560COMPLETEDNA
708 participants
INTERVENTIONAL
New Delhi, India +1 more
Started: Sep 26, 2018
Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patients
NCT06983223COMPLETEDNA
50 participants
INTERVENTIONAL
Jāmshoro, Pakistan
Started: Aug 15, 2025