Sublingual Cobalamin (Cyanocobalamin/Methylcobalamin)
Treatment for Vitamin B12 Deficiency
Typical Dosage: 1000-2000 mcg daily
Effectiveness
97%
Safety Score
90%
Clinical Trials
2
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
90
DangerousModerateSafe
Treatment Details
Dosage Range
1000-2000 mcg daily
Time to Effect
Hematologic: 5-7 days; Symptomatic: 1-4 weeks; Neurological: Weeks to months
Treatment Duration
Lifetime for chronic deficiency
Evidence Quality
MODERATE TO HIGHConfidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$100
Side Effect Mgmt:$5
Total Annual:$155
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.8
Outcome-Based Costs
Cost per Responder
$159.79
Cost per Remission
$172.22
Comparison vs No treatment
Cost Difference
$-155/year
Less expensive
QALY Difference
+0.80 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Sublingual Cobalamin (Cyanocobalamin/Methylcobalamin) Outcomes
for Vitamin B12 Deficiency
Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+90%
Common Side Effects
Mild GI upset
+1%
Allergic reactions
+0.05%
Sources:
Active Clinical Trials
1 active trial recruiting for Sublingual Cobalamin (Cyanocobalamin/Methylcobalamin) in Vitamin B12 Deficiency
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
NCT06966856NOT YET RECRUITINGPHASE3
23 participants
INTERVENTIONAL
Started: Dec 30, 2026