Metformin | Decentralized FDA

MetforminIntake and Interventions

First-line medication for the treatment of type 2 diabetes.

Correlation

Metformin Dosage(baseline: 500 mg/day)

+300% (+1500 mg) (NNH: 9999)

Efficacy

Fasting Blood Glucose(baseline: 150 mg/dL)

-6.67% (-10 mg/dL) (NNH: 9999)

HbA1c(baseline: 7.5%)

-9.33% (-0.7 %) (NNH: 9999)

Body Weight(baseline: 90 kg)

-2.78% (-2.5 kg) (NNH: 9999)

Waist Circumference(baseline: 100 cm)

-2% (-2 cm) (NNH: 9999)

Triglycerides(baseline: 170 mg/dL)

-8.82% (-15 mg/dL) (NNH: 9999)

HDL Cholesterol(baseline: 45 mg/dL)

+4.44% (+2 mg/dL) (NNH: 9999)

LDL Cholesterol(baseline: 120 mg/dL)

-4.17% (-5 mg/dL) (NNH: 9999)

Mechanism

Fasting Insulin(baseline: 15 μU/mL)

-13.33% (-2 /uL) (NNH: 9999)

Insulin Resistance (HOMA-IR)(baseline: 3.0)

-16.67% (-0.5 1) (NNH: 9999)

Safety

Gastrointestinal Side Effects(baseline: 0, no side effects)

+40% (+2 1-5) (NNH: 5)

Source:

AI Generated Relationships (models/gemini-1.5-pro-latest)

Google AI. 2025.

NNH = Number Needed to Harm